In Progress: NFL Preseason Kicks Off For Manning, Colts Against 49ers

Indianapolis, IN (Sports Network) - Rookie Anthony Dixon carried the ball 21 times for 100 yards and a score, as the San Francisco 49ers dominated the Indianapolis Colts, 37-17, in the preseason opener for each club.

Alex Smith completed 3-of-9 passes for 37 yards and an interception for the 49ers, who are coming off an 8-8 season. Veteran offseason acquisition David Carr connected on 9-of-11 passes for 98 yards and a touchdown.

Michael Robinson rushed for a TD and Tony Curtis caught a touchdown pass for San Francisco, which recorded four interceptions on defense. Reggie Smith returned a pick 91 yards for a touchdown.

Peyton Manning connected on 8-of-10 passes for 91 yards for the Colts, who were in action for the first time since their 31-17 loss to the New Orleans Saints in Super Bowl XLIV.

Curtis Painter showed why Manning needs to stay healthy in order for Indianapolis to succeed. The Purdue product threw three interceptions while completing 9-of-19 passes for 64 yards. Fellow second-year pro Tom Brandstater connected on 8-of-12 passes for 34 yards, a touchdown, and interception.

Joseph Addai carried the ball five times for 11 yards and a score. Jacob Tamme caught three passes for 26 yards and a TD.

The Colts jumped out to a 10-0 lead in the first quarter on Adam Vinatieri's 21-yard field goal and Addai's seven-yard TD run.

Smith got the 49ers rolling when he picked off Painter's pass and returned it for a touchdown early in the second quarter. Robinson's three-yard TD run on the ensuing San Francisco possession gave the visitors a 14-10 lead.

Shane Andrus added a pair of field goals before the half to give the 49ers a 10-point cushion and the visitors cruised to victory in the second half.