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NFL Expert Picks for Week 16 of 2025

Here are our picks for Week 16.

by James Dator
Seattle Seahawks v Los Angeles Rams - NFL 2025
Seattle Seahawks v Los Angeles Rams - NFL 2025
Getty Images

Been waiting all week for Thursday night. That’s how the saying goes, right? This week the biggest game on the NFL slate comes from Thursday Night Football between the Rams and Seahawks, in an NFC West divisional matchup that could settle who wins the west and earns a first round bye, and who could find themselves in a road wild cad game.

When it comes to Thursday night we have a totally split panel, with five thinking the Rams will win, and five believing in the Seahawks. That’s not the only critical game of the week with the Panthers and Buccaneers facing off in what could determine the NFC South, as well as the Jaguars and Broncos battling atop the AFC.

Here are our picks for Week 16.

Week 16

Mookie Alexander

James Dator

Chet Gresham

Brandon Lee Gowton

Jared Mueller

R.J. Ochoa

Ricky O’Donnell

Mark Schofield

Nick Simon

Matt Warren

TNF: Rams vs. SeahawksRamsRamsSeahawksRamsSeahawksSeahawksRamsSeahawksRamsSeahawks
Eagles vs. CommandersEaglesEaglesEaglesEaglesEaglesEaglesEaglesEaglesEaglesEagles
Packers vs. BearsBearsPackersPackersPackersBearsBearsBearsBearsBearsPackers
Chargers vs. CowboysChargersCowboysChargersCowboysChargersChargersCowboysChargersCowboysChargers
Vikings vs. GiantsVikingsVikingsVikingsVikingsVikingsVikingsGiantsVikingsVikingsVikings
Bengals vs. DolphinsBengalsBengalsDolphinsBengalsBengalsBengalsBengalsBengalsBengalsBengals
Buccaneers vs. PanthersPanthersPanthersBucsBuccaneersPanthersPanthersBucsPanthersBuccaneersPanthers
Jets vs. SaintsSaintsSaintsSaintsSaintsSaintsSaintsSaintsSaintsSaintsSaints
Bills vs. BrownsBillsBillsBillsBillsBillsBillsBillsBillsBillsBills
Chiefs vs. TitansTitansTitansChiefsChiefsChiefsTitansChiefsTitansChiefsChiefs
Jaguars vs. BroncosBroncosBroncosBroncosJaguarsBroncosBroncosBroncosBroncosBroncosBroncos
Falcons vs. CardinalsFalconsFalconsCardinalsFalconsCardinalsFalconsFalconsFalconsFalconsFalcons
Raiders vs. TexansTexansTexansTexansTexansTexansTexansTexansTexansTexansTexans
Steelers vs. LionsLionsLionsSteelersLionsLionsLionsLionsSteelersLionsSteelers
SNF: Patriots vs. RavensPatriotsPatriotsPatriotsRavensPatriotsPatriotsRavensPatriotsPatriotsRavens
MNF: 49ers vs. Colts49ers49ers49ers49ersColts49ers49ers49ers49ers49ers
2025 Pick record127-79-1129-77-1131-75-1131-75-1115-91-1125-81-1140-66-1132-74-1128-78-1136-70-1
See More:

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