Skip to main content
Come Fan with UsSunday, June 21, 2026

NFL Odds And Lines Week 12: 49ers Vs. Ravens

The San Francisco 49ers and Baltimore Ravens will face-off in the Harbaugh Bowl this Thanksgiving. The Ravens are the favorites, but the lines has been dropping closer to the 49ers as Vegas remembers they’ve lost just one time this season.

The San Francisco 49ers will play the Baltimore Ravens on Thursday night to end the NFL's Thanksgiving marathon. The game features quite a few interesting storylines, not the least of which is the match-up between the Harbaugh brothers, but this particular story is focusing on the Week 12 odds and lines.

The Ravens opened the week as 4½-point favorites over the Frank Gore led 49ers, but the line has dropped at least one point since Monday on most of the major sites, according to the excellent database at Odds Shark. Considering San Francisco has just one loss on its record through its first 10 weeks of the season, Vegas is obviously showing quite a bit of confidence in Joe Flacco, Ray Rice and the rest of the Ravens.

The over-under on the NFL Network’s game of the week is sitting at 40 points, give or take a point, heading into Thursday night. Considering it’s likely to be a defensive battle, it might be better to just bet on the Harbaugh of your choosing.

For more on the 49ers, be sure to check out Niners Nation. For the best Ravens community on the web, Baltimore Beat Down is the place to be. SB Nation’s NFL odds page should be the first stop for lines for all of the other games this week.

See More:

More in NFL

NFL
WNFC championship game airing Sunday, June 21st from Ford Center in FriscoWNFC championship game airing Sunday, June 21st from Ford Center in Frisco
NFL

The Women’s National Football Conference Championship will air on ESPN2 this weekend.

By RJ Ochoa
From SBNationExternal Link
Which fictional quarterback would you have lead your team?Which fictional quarterback would you have lead your team?
From SBNationExternal Link
By James Dator
NFL
Best bets for 2026 NFL Offensive Rookie of the YearBest bets for 2026 NFL Offensive Rookie of the Year
NFL

There are some good longer-shot options on offensive side of ball for the NFL’s Rookie of the Year.

By Bill Williamson
NFL
Brendan Sorsby is a rare chance to get a top QB cheap, and these teams should go inBrendan Sorsby is a rare chance to get a top QB cheap, and these teams should go in
NFL

This is a no-brainer for some NFL teams.

By James Dator
NFL
Fernando Mendoza has great respect for the Raiders that came before himFernando Mendoza has great respect for the Raiders that came before him
NFL

Fernando Mendoza has great respect for the Raiders that came before him

By RJ Ochoa
NFL
Brendan Sorsby intends to enter NFL Supplemental Draft, per reportsBrendan Sorsby intends to enter NFL Supplemental Draft, per reports
NFL

Texas Tech quarterback Brendan Sorsby is entering the NFL Supplemental Draft, per reports

By Mark Schofield