The San Francisco 49ers are 6.5-point favorites over the New York Giants heading into their game on Sunday at Candlestick Park, and most NFL experts are picking San Francisco to win the rematch of last season's NFC Championship game.
Week 6 NFL picks: Giants vs. 49ers
Most NFL experts are picking the San Francisco 49ers to oust the New York Giants in Sunday’s rematch of last season’s NFC Championship game.


All but one of ESPN’s crew of 12 NFL Experts is picking San Francisco to win. Eric Allen is the lone contrarian, picking the Giants in an upset.
The trio of experts at Yahoo! have picked the 49ers across the board, while most of the expert team at CBSSports.com is leaning in favor of the Giants in the Week 6 showdown. Six of the site’s eight experts are picking New York, while Clark Judge and Dave Richard are sticking with the oddsmakers and calling a 49ers win.
Sports Illustrated’s Peter King is also siding with the 49ers, picking them to down the Giants, 24-16.
Kickoff is scheduled for 4:25 p.m. ET and the game will be televised on FOX.











