Skip to main content
Come Fan with UsSaturday, June 20, 2026

Week 6 NFL picks: Giants vs. 49ers

Most NFL experts are picking the San Francisco 49ers to oust the New York Giants in Sunday’s rematch of last season’s NFC Championship game.

Brian Bahr - Getty Images

The San Francisco 49ers are 6.5-point favorites over the New York Giants heading into their game on Sunday at Candlestick Park, and most NFL experts are picking San Francisco to win the rematch of last season's NFC Championship game.

All but one of ESPN’s crew of 12 NFL Experts is picking San Francisco to win. Eric Allen is the lone contrarian, picking the Giants in an upset.

The trio of experts at Yahoo! have picked the 49ers across the board, while most of the expert team at CBSSports.com is leaning in favor of the Giants in the Week 6 showdown. Six of the site’s eight experts are picking New York, while Clark Judge and Dave Richard are sticking with the oddsmakers and calling a 49ers win.

Sports Illustrated’s Peter King is also siding with the 49ers, picking them to down the Giants, 24-16.

Kickoff is scheduled for 4:25 p.m. ET and the game will be televised on FOX.

See More:

More in NFL

NFL
WNFC championship game airing Sunday, June 21st from Ford Center in FriscoWNFC championship game airing Sunday, June 21st from Ford Center in Frisco
NFL

The Women’s National Football Conference Championship will air on ESPN2 this weekend.

By RJ Ochoa
From SBNationExternal Link
Which fictional quarterback would you have lead your team?Which fictional quarterback would you have lead your team?
From SBNationExternal Link
By James Dator
NFL
Best bets for 2026 NFL Offensive Rookie of the YearBest bets for 2026 NFL Offensive Rookie of the Year
NFL

There are some good longer-shot options on offensive side of ball for the NFL’s Rookie of the Year.

By Bill Williamson
NFL
Brendan Sorsby is a rare chance to get a top QB cheap, and these teams should go inBrendan Sorsby is a rare chance to get a top QB cheap, and these teams should go in
NFL

This is a no-brainer for some NFL teams.

By James Dator
NFL
Fernando Mendoza has great respect for the Raiders that came before himFernando Mendoza has great respect for the Raiders that came before him
NFL

Fernando Mendoza has great respect for the Raiders that came before him

By RJ Ochoa
NFL
Brendan Sorsby intends to enter NFL Supplemental Draft, per reportsBrendan Sorsby intends to enter NFL Supplemental Draft, per reports
NFL

Texas Tech quarterback Brendan Sorsby is entering the NFL Supplemental Draft, per reports

By Mark Schofield