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Come Fan with UsSaturday, June 20, 2026

Seattle Seahawks vs San Francisco 49ers: betting odds, preview, trends, picks

Seattle has lost three straight at San Francisco, but they have been absolutely vicious as underdogs. They get 7.5 points on Thursday night, more than enough to get the attention of underdog bettors.

If we have learned anything from the 2012 NFL season, it’s that the Seattle Seahawks pack a nasty bite as an underdog.

Just ask the Green Bay Packers, New England Patriots and Dallas Cowboys. By Friday morning, we might be able to ask San Francisco 49ers bettors the same question.

Seattle is 13-2-1 ATS in their past 16 games as an underdog and about 56 percent of the early betting action was on them, according to the NFL betting consensus numbers at OddsShark.com.


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First place in the NFC West is on the line this Thursday night when the 49ers host the Seahawks at Candlestick Park. San Francisco was an 8-point home favorite to open the week, but sportsbooks now have them at -7 or -7.5.

“Seattle has proven to run hot and cold, usually cold on the road, so we continue to take lots of 49er action, in spite of the Seahawks record as an underdog,” said Scott Winstone of TopBet. “The Seahawks have lost three straight here and the NFL betting situation has been the same as they are 0-3 ATS in those games.”

Across all sports, there are some instances where one team simply has another team’s number. Many expected the San Francisco 49ers to get their revenge on the New York Giants for last year’s loss in the NFC Conference Finals, but instead the Giants bested the 49ers once again, this time by a blowout score of 26-3.

San Francisco is now 9-2 SU and ATS in its last 11 games at home; 0-2 SU and ATS against the New York Giants and 9-0 SU and ATS against everyone else. The 49ers are 4-2 SU and ATS this season.

At this point in the season it has become pretty clear that the Seahawks have a flair for the dramatic.

They needed some help from the replacement referees against Green Bay and once again last Sunday with a late touchdown pass to Sidney Rice to upset the New England Patriots 24-23. Like San Francisco, Seattle is 4-2 both SU and ATS.

These two teams have been virtually neck and neck in head-to-head competition over the last five years, splitting their last 10 games 5-5 SU with Seattle holding a slight 6-4 ATS advantage. San Francisco has held the recent advantage however with three straight wins over their division rival (2-1 ATS).

San Francisco is 3-0 SU and ATS in its last three home games against Seattle, which coupled with its 9-2 SU and ATS run makes the 49ers a very scary road team.

Seattle is just 4-11 SU in its last 15 road games and 7-14-1 ATS in its last 22 road games.

But with that said, seven points is too many. Seattle has been great on defense this season allowing just 15.5 points per game, and in what should be a defensive showdown between two division rivals on primetime, we’ll take the points.

PICK: Seattle +7.5 (courtesy of PickShark.com and follow us on Twitter for odds and injury updates)

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