The 3-1 San Francisco 49ers are favored by eight points over the 2-2 Buffalo Bills.
49ers rout Bills, win 45-3
Jason O. Watson - Getty ImagesThe win moved the 49ers to 4-1 and into a tie for first place in the NFC West. The Bills dropped to 2-3 and have now lost two straight games.
Fantasy studs and duds
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Elsa - Getty ImagesBrandon Jacobs, LaMichael james still out
Ed Szczepanski-US PRESSWIRE - PresswireThe 49ers will be without seven players as well, headlined by running back Brandon Jacobs, who injured his knee in the preseason. Jacobs had said earlier in the week that he hoped to make his season debut against the Bills.
A complete inactive list for San Francisco is below.
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