NFL picks and predictions, Titans vs. Patriots 2015: New England is unanimous pick to win

The injuries are mounting in New England, but that shouldn't slow down the Patriots this weekend as they host the 3-10 Tennessee Titans on Sunday afternoon.

The latest player to land on injured reserve was LeGarrette Blount, who was the Patriots' leading rusher through the first three months. His 703 rushing yards are nearly seven times more than any other running back on the active roster. Brandon Bolden and James White are expected to get the majority of the carries going forward, but haven't been very effective on the ground in limited action. Bolden is averaging 3.1 yards per rush and White is at 2.6.

While the Pats lost Blount last week, they did get back the team's most important weapon in tight end Rob Gronkowski, who had an instant impact on the offense with four catches for 87 yards and a touchdown. It also helped the Patriots return to the win column as they beat Houston to clinch a playoff berth for the 13th time in the last 15 years.

With Denver and Cincinnati both losing last week, the Patriots now have the inside track for homefield advantage throughout the playoffs. They can secure a first-round bye on Sunday with a win over the Titans and a loss by the Broncos. If the Broncos somehow tie the Steelers, they'd need the Bengals to lose as well in order to clinch one of the top two seeds.

Even with a depleted roster, beating the Titans shouldn't be a problem for the Patriots. They've won four straight in the series and have regularly dominated AFC South teams. New England is 11-0 against the division since 2010 with an average margin of victory of 17 points per game. The Patriots also haven't lost to a team that finished with double-digit losses since getting beat by the Cardinals (5-11) in Week 2 of the 2012 season.