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Come Fan with UsFriday, July 3, 2026

Broncos vs. Colts: Betting odds, pick, preview & trends

Peyton Manning is favored on the road again and the computer says he will easily win his return to Indianapolis. But Week 7 betting trends favor the Colts, even as the odds favor the Broncos by a TD.

Joey Foley

The Indianapolis Colts are a perfect 7-0 SU and ATS in their last 10 games as a home underdog, and they get a chance to extend that streak against a team they have dominated against the spread.

They will look to keep both streaks alive when they host the Denver Broncos this Sunday night. Indianapolis, 5-0 SU and ATS against the Broncos, was a 6.5-point home underdog midweek at most sportsbooks monitored by OddsShark.com.

Indianapolis put together three straight impressive wins with a road win over San Francisco, a blowout win over Jacksonville and a home upset over the Seattle Seahawks. But whether the Colts were simply due for a letdown or were looking ahead to this week’s game against Denver, the team simply didn’t have it in a 19-9 loss to the San Diego Chargers on Monday night.

The defense has allowed just 16.3 points per game this season and played well on Monday night, but Andrew Luck and the offense had an off night.

The Denver Broncos had their version of an off-night on offense last Sunday too, scoring a season-low 35 points in a 35-19 win over the Jacksonville Jaguars. Going up against the worst team in the league, the Broncos looked like they were just going through the motions and failed to cover as a 26.5-point favorite.

Overall, Denver is now 17-0 SU and 12-5 ATS over its last 17 regular season games, and is averaging a staggering 44.2 points per game on offense this season.

The Indianapolis Colts are 8-2 SU and ATS in their last 10 games against the Denver Broncos, but the most recent meeting between these two teams came in 2010. Peyton Manning was on the other sideline for those 10 games.

This is the storyline of the night as Peyton Manning makes what should be an emotional return to Indianapolis, playing here for the first time in another team’s jersey.

As good as the Colts have looked this season, you can’t pass on the Broncos when they need to cover less than a touchdown, and it’s hard to see Peyton Manning not flourishing with the national stage set for him on Sunday Night Football.

PICK: Denver -6.5 | Computer Prediction: 42-33 Denver

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