The San Francisco 49ers are 11-2 straight up and 10-2-1 against the spread in their last 13 games as a road favorite and have been dominant on Monday Nights over the year. The 49ers will go for another win as a road favorite on Monday night visiting the St. Louis Rams.
49ers vs. Rams, Monday Night Football: Betting odds, prediction
San Francisco is looking for third straight win at St. Louis on Monday night continuing its MNF domination (25-8-1 ATS over past 20 seasons).


San Francisco is a 3-point favorite on Monday night according to sportsbooks monitored by OddsShark.com. With a proven record on the road and a chance to move ahead of the Seattle Seahawks in the standings, the 49ers should bring their best game on Monday and pick up a win and cover.
After getting off to a 1-2 SU and ATS start to the season, rumors were swirling around the 49ers and head coach Jim Harbaugh. But the 49ers have bounced back nicely with back-to-back wins against Philadelphia and Kansas City.
NFL Week 6
Still, the 49ers haven’t looked dominant since their opening game against Dallas; both of those wins came by only five points each. The total has gone UNDER in each of San Francisco’s last three games.
OddsShark Computer Prediction: San Francisco 25, St. Louis 18.2
San Francisco takes on St. Louis at 8:30pm ET at the Edward Jones Dome.
When Sam Bradford went down during the preseason, many believed that the Rams would be in bad shape on offense all season. But they’ve found their guy in Austin Davis, who has thrown for 702 yards and six passing touchdowns over the last two weeks.
Unfortunately for the Rams, the defense hasn’t done its part, giving up 34 points in each of those games to fall to 1-3 SU and ATS on the season. St. Louis will try to tighten up the defense on Monday.
The UNDER is 4-0 in San Francisco’s last four games as a road favorite and 2-1 in the last three games between these two teams. Monday night’s total is set at 43.5 points at sportsbooks monitored by OddsShark.com.
St. Louis has one of the worst rushing defenses in the league allowing 152.5 rushing yards per game. This doesn’t match up well against the 49ers who have the third ranked rushing offense in the NFL. San Francisco should set the tempo on the ground and cover the spread as a 3-point favorite.











