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Come Fan with UsThursday, July 2, 2026

Harvard vs. Cincinnati betting matchup, East Region prediction

Harvard is an underdog, but the computer predicts they will upset slumping No. 5 seed Cincinnati.

A 5 seed is in trouble in the East Region, as Cincinnati is a 3-point favorite taking on 12-seed Harvard.

Cincinnati went 27-6 SU this season to earn an at-large bid into the NCAA tournament. The Bearcats rank sixth in the nation on defense allowing only 58.3 points per game, leading the team to go 20-7 on the UNDER this season.

But Cincinnati went just 3-8 ATS over its last 11 games.

The Harvard Crimson are a dangerous 12-seed, amassing a 26-4 SU and 16-7-1 ATS record this season en route to an Ivy League title. Like Cincinnati, Harvard has a stingy defense that allowed only 60.5 PPG this season.

The UNDER is 9-1 in Harvard’s last 10 games as an underdog.

The computer is picking a 65-62 win for Harvard.

Cincinnati vs Harvard, East Region betting trends

Cincinnati 1-4 ATS past five games

OVER is 6-1-1 past 8 first-round games for Bearcats

Harvard 26-4 SU past 30 games

Harvard 6-1 ATS final seven games of 2014 Ivy League season

UNDER is 9-1 past 10 games when Harvard underdog

See the latest March Madness odds, matchup reports and trends on every game and follow live lines and your bracket picks with the free OddsShark.com odds app.

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