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Come Fan with UsThursday, July 2, 2026

Louisville vs Saint Louis betting highlights Midwest bracket odds, picks

Louisville is favored big over Saint Louis while Michigan lays a few points to Texas in a 2 vs 7 matchup (that has been one-sided in recent years). See Midwest betting odds and trends.

Since 1996, Louisville is 4-1 ATS in five games as a Round of 32 favorite in the NCAA Tournament.

The 4-seed Cardinals will be in that position again on Saturday as a 9-point favorite squaring off against 5-seed Saint Louis. Shortly afterward, the Midwest bracket continues with 2-seed Michigan as a 4.5-point favorite over 7-seed Texas.

[ Search the free Madness database for every team against any seed ]

Louisville remains one of the hottest teams in the nation with a 12-1 SU and 9-4 ATS record over its last 13 games. No. 4-seeds are 6-1 ATS against 5-seeds in seven 4 vs. 5 matchups since 2010. The total has gone UNDER in seven of Louisville’s last 10 games and in each of its last two.

The Amway Center in Orlando hosts the Saint Louis vs. Louisville game at 2:45pm ET. The Midwest bracket’s Saturday action wraps up in Milwaukee with Texas vs. Michigan at 5:15pm.

Saint Louis’ come from behind win over North Carolina State improved the Billikens to 2-1 SU and 1-1-1 ATS over their last three games after going 0-3 SU and ATS in their previous three.

The Billikens are just 1-8-1 ATS over their last 10 games, but enter with momentum after overcoming an 11-point deficit at the sportsbooks to beat NC State.

With Michigan’s 57-40 win and cover over Wofford, the Wolverines improved to 8-1 SU and 5-4 ATS over their last nine games. Recent history is on Michigan’s side Saturday as 2-seeds are 10-0 SU in their last 10 games against 7-seeds.

The total has gone UNDER in Michigan’s last two games after going OVER in its previous four games.

Texas entered its game against ASU on a 3-5 SU and 2-6 ATS skid, but picked up an 87-85 win on a buzzer-beating basket to advance as a 2-point favorite. Cameron Ridley led the way on offense with 17 points and 12 rebounds in the game.

The Longhorns are 0-3 SU but 3-0 ATS in three tournament games against 2-seeds since 1996.

See the latest March Madness odds, matchup reports and trends on every game and follow live lines and your bracket picks with the free OddsShark.com odds app.

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