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Come Fan with UsWednesday, July 1, 2026

Chicago Bears at San Francisco 49ers betting preview, pick & trends

The Niners are favored at home against a Bears team coming off a lame home opening loss to Buffalo. Expect this number to climb in the SNF game.

Cary Edmondson-US PRESSWIRE

The San Francisco 49ers are 12-3 SU and 11-4 ATS in their last 15 games as a home favorite of a touchdown or less, which is the role they find themselves in hosting the Chicago Bears this Sunday night.

The line

San Francisco matches up well with the Chicago Bears, and in its home opener the 49ers should be able to win and cover the 6.5-point spread against Chicago.

The history

The final score of 28-17 didn't do justice to how much the San Francisco 49ers dominated the Dallas Cowboys last Sunday. After taking a 28-3 lead and winning the turnover battle 3-0 with three interceptions in the first half, the 49ers went into cruise control and held on for a 28-17 lead as a 3-point road favorite.

San Francisco is 9-1 SU and 6-3-1 ATS in its last 10 games overall.

Chicago's rushing defense was awful last Sunday against the Buffalo Bills, giving up 193 yards on 33 carries. Favored by 6.5 points, Chicago lost outright to the Bills in a surprising 23-20 final score.

The Bears are just 3-6 SU and 2-7 ATS in their last nine games overall. The Bears are also only 2-5 SU and ATS in their last seven road games.

With Chicago turning to the passing game on offense and dealing with a declining defense in recent years, the Bears have trended heavily toward the OVER. The OVER is 7-1 over Chicago’s last eight games and 12-3 over the Bears’ last 15 games on the road.

The San Francisco 49ers are a terrible matchup for the Chicago Bears on paper. San Francisco has one of the best running games in the league, which should have a field day against this rushing defense.

And while the Bears will win games this year behind the arm of Jay Cutler, they aren't likely going to be able to put up a ton of points on the road against this stingy defense.

The pick

Both the matchup on paper and the recent play of these two teams point to a comfortable win and cover for the San Francisco 49ers as 6.5-point favorites Sunday night.

Odds Shark Computer Prediction: 30-21 SF

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