No. 1 Florida State returns to action after a bye in Week 3 and is pegged as 19.5-point home favorites against No. 22 Clemson, according to sportsbooks monitored by OddsShark. It has been eight years since the Tigers recorded a road win against the Seminoles, who have won nine straight at home, at 7-2 against the spread, and 16 straight overall dating back to 2012.
College football odds: Week 4 opening spreads favor top-ranked teams
Another crazy week in college football betting is behind. Is more in store on the odds menu?
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Clemson dominated South Carolina State 73-7 as 34-point favorites in Week 2 to move to 12-2 SU in its last 14 games. However, going into Saturday’s Seminoles vs. Tigers matchup at Doak Campbell Stadium, Clemson has covered just once in its last four games as road underdogs.
Full Week 4 college football opening spreads, courtesy of OddsShark.com
| Auburn at Kansas State | 6.5 | |
| Connecticut at South Florida | -2.5 | |
| Troy at Georgia | -35.5 | |
| Georgia Tech at Virginia Tech | -6 | |
| Idaho at Ohio | -13 | |
| Eastern Michigan at Michigan State | -45 | |
| Southern Illinois at Purdue | OFF | |
| Old Dominion at Rice | -10 | |
| Bowling Green at Wisconsin | -17 | |
| Iowa at Pittsburgh | -4 | |
| Western Illinois at Northwestern | OFF | |
| Tulane at Duke | -17.5 | |
| Maryland at Syracuse | -1.5 | |
| Delaware State at Temple | OFF | |
| Maine at Boston College | OFF | |
| Marshall at Akron | 12.5 | |
| Hawaii at Colorado | -7 | |
| Army at Wake Forest | -3 | |
| Central Michigan at Kansas | OFF | |
| Virginia at BYU | -13.5 | |
| Florida at Alabama | -16 | |
| North Carolina at East Carolina | 2 | |
| Norfolk State at Buffalo | OFF | |
| Nicholls State at North Texas | OFF | |
| Louisville at Florida International | 27 | |
| Texas A&M at Southern Methodist | 28 | |
| Rutgers at Navy | OFF | |
| Utah at Michigan | -6.5 | |
| San Jose State at Minnesota | -6.5 | |
| Texas State at Illinois | -14 | |
| Massachusetts at Penn State | -30 | |
| Indiana at Missouri | -16 | |
| Florida Atlantic at Wyoming | -3.5 | |
| Bethune-Cookman at Central Florida | OFF | |
| Presbyterian at North Carolina State | OFF | |
| Georgia State at Washington | -36.5 | |
| Northern Illinois at Arkansas | -8 | |
| Middle Tennessee at Memphis | -7.5 | |
| Ball State at Toledo | -9 | |
| Murray State at Western Michigan | OFF | |
| Northwestern State at Louisiana Tech | OFF | |
| Miami (Ohio) at Cincinnati | -32 | |
| Utah State at Arkansas State | OFF | |
| Appalachian State at Southern Miss | -4 | |
| Mississippi State at LSU | -7 | |
| Georgia Southern at South Alabama | -2.5 | |
| South Carolina at Vanderbilt | 20.5 | |
| Oklahoma at West Virginia | 11 | |
| Miami at Nebraska | -8 | |
| Clemson at Florida State | -20.5 | |
| New Mexico at New Mexico State | OFF | |
| UNLV at Houston | OFF | |
| California at Arizona | -16 | |
| S. Utah at Fresno State | OFF | |
| Louisiana-Lafayette at Boise State | -17 | |
| Oregon at Washington State | 19.5 | |
| San Diego State at Oregon State | -8.5 |
Virginia Tech is just 2-4 against the spread in its last six games against Georgia Tech, welcoming the Yellow Jackets to town as 8-point home favorites this weekend. The Hokies dropped out of the AP Top 25 following their disappointing 28-21 loss to East Carolina as 10-point home underdogs in Week 3. The loss was a serious letdown for Virginia Tech, coming on the heels of its 35-21 win over Ohio State in Week 2. Virginia Tech has won the last four meetings with Georgia Tech straight up, but will be facing a Yellow Jackets squad that is a perfect 3-0 SU in 2014.
No. 14 South Carolina will be gunning for a third straight win when it visits the Vanderbilt Commodores on Saturday night. The Gamecocks open as 21.5-point road favorites following a confidence-building 38-35 win over Georgia. The Gamecocks held off a late fourth-quarter drive by the Dawgs for the win, covering as 8.5-point underdogs to remain in the AP Top 25. Vandy posted its first win of the season in Week 3, 34-31 over Massachusetts, but failed to cover as 16.5-point home favorites. The Commodores have dropped five straight SU to South Carolina, but are 5-2 ATS in their last seven games against the Gamecocks.
In other Week 4 betting action, No. 2 Oregon will look to end a two-game road losing streak when the Ducks visit Washington State as 23.5-point favorites, according to sportsbooks monitored by OddsShark. The Cougars are coming off a 59-21 win over Portland State, their first SU win in five games. No. 4 Oklahoma opened as 11.5-point road favorites against the West Virginia Mountaineers, while No. 5 Auburn travels to Kansas State as 9.5-point favorites.
