The No. 2 Oregon Ducks are just 2-7 against the spread in their last nine games as a double-digit favorite. They will be in that role on Thursday hosting the Arizona Wildcats at Autzen Stadium. Oregon is a 22.5-point favorite at home at sportsbooks monitored by OddsShark.com. Both Oregon and Arizona are off to matching 4-0 straight up and 1-3 ATS starts to the 2014 season. Arizona beat Oregon as an 18.5-point home underdog last season after going 0-5 SU and 2-3 ATS in its previous four games against the Ducks.
College football opening odds, Week 6: Oregon, Alabama favored in big games
Oregon is a double-digit favorite again in Pac 12 betting vs Arizona as Week 6 college football odds opened Monday.
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No 6. Texas A&M is visiting No. 12 Mississippi State in what will be the first of six matchups between two ranked teams on Saturday. Mississippi State is 8-1 ATS in its last nine games and is a 1-point favorite at home on Saturday.
No. 3 Alabama is a 5.5-point road favorite, according to sportsbooks monitored by OddsShark.com, visiting the No. 11 Mississippi Rebels on Saturday. Ole Miss is 6-3 ATS in its last nine games against Alabama and 6-2 ATS in its last eight home games overall.
After beating West Virginia 45-33 in is first big road test of the season, the No. 4 Oklahoma Sooners get another road test this Saturday afternoon, visiting the No. 25 TCU Horned Frogs. TCU is a 4.5-point underdog at home and will try to turn its conference luck around, following a 1-7 ATS record in its last eight games against Big 12 opponents.
No. 9 Notre Dame hosts No. 14 Stanford in Notre Dame’s first of three games against Pac-12 opponents this season. The UNDER is 4-0 in the last four meetings between these two teams and 4-0 in Notre Dame’s last four games against Pac-12 opponents. Stanford is a 1.5-point home favorite.
Rounding out the games between two ranked teams in the early evening are No. 15 LSU vs. No. 5 Auburn and No. 19 Nebraska vs. No. 10 Michigan State. Auburn is a 9-point favorite at home against LSU while Michigan State is going off at -9.5 at home against the Cornhuskers. Michigan State is 6-2 ATS in its last eight games at home according to the OddsShark College Football Database.
Opening college football lines aggregated by OddsShark.com:
| Central Florida at Houston | -2.5 | |
| Florida Atlantic at Florida International | 9 | |
| Arizona at Oregon | -22.5 | |
| Louisville at Syracuse | 3.5 | |
| San Diego State at Fresno State | 2 | |
| Utah State at BYU | OFF | |
| Iowa State at Oklahoma State | -17 | |
| Texas A&M at Mississippi State | 1 | |
| Marshall at Old Dominion | 17.5 | |
| Ohio State at Maryland | OFF | |
| Southern Methodist at East Carolina | -35.5 | |
| Southern Miss at Middle Tennessee | -16.5 | |
| Purdue at Illinois | OFF | |
| Florida at Tennessee | 1.5 | |
| Ball State at Army | -3 | |
| Virginia Tech at North Carolina | 1.5 | |
| Eastern Michigan at Akron | -21 | |
| Massachusetts at Miami (Ohio) | -4.5 | |
| North Texas at Indiana | -13.5 | |
| Tulsa at Colorado State | -14.5 | |
| Navy at Air Force | 4 | |
| Ohio at Central Michigan | OFF | |
| Wisconsin at Northwestern | 9.5 | |
| North Carolina State at Clemson | -14 | |
| Buffalo at Bowling Green | -5 | |
| Baylor at Texas | 13 | |
| Alabama at Mississippi | 4.5 | |
| Stanford at Notre Dame | PK | |
| Wake Forest at Florida State | -38 | |
| New Mexico at UTSA | -18.5 | |
| Oklahoma at TCU | 5 | |
| Arizona State at Southern Cal | -10.5 | |
| Kansas at West Virginia | -23.5 | |
| Oregon State at Colorado | 7.5 | |
| Vanderbilt at Georgia | -32.5 | |
| Kent State at Northern Illinois | -22 | |
| South Alabama at Appalachian State | 5.5 | |
| Georgia State at Louisiana-Lafayette | -17 | |
| LSU at Auburn | -9 | |
| Utah at UCLA | -12.5 | |
| Idaho at Texas State | -14.5 | |
| Hawaii at Rice | -6 | |
| Texas Tech at Kansas State | OFF | |
| Louisiana-Monroe at Arkansas State | -10 | |
| Michigan at Rutgers | -3.5 | |
| UAB at Western Kentucky | -14 | |
| Texas El Paso at Louisiana Tech | -13 | |
| Toledo at Western Michigan | 10 | |
| Memphis at Cincinnati | -6.5 | |
| Miami at Georgia Tech | -1 | |
| Pittsburgh at Virginia | -4 | |
| South Carolina at Kentucky | 7.5 | |
| Nebraska at Michigan State | -8 | |
| UNLV at San Jose State | OFF | |
| Ga Southern at New Mexico State | 16.5 | |
| Boise State at Nevada | 1.5 | |
| California at Washington State | -4 |
