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Come Fan with UsFriday, June 26, 2026

Patriots vs. Bills 2016 odds: New England set as road favorite in revenge game at Buffalo

The New England Patriots have strong betting trends on their side for Sunday afternoon as they take on the Buffalo Bills as clear odds favorites.

Charles LeClaire-USA TODAY Sports

The New England Patriots are 11-1 straight up and 9-2-1 against the spread in their last 12 games on the road against the Buffalo Bills. The Patriots will try to win in Buffalo for the fifth straight season this Sunday afternoon.

New England is a 6.5-point road favorite at New Era Field at sportsbooks monitored by OddsShark.com. The line opened at New England -4.5, but early action on the Patriots has moved the line two full points.

The Patriots were solid without Tom Brady, going 3-1 SU and ATS in his absence. But in the three games since Brady’s return, New England has been completely dominant, averaging 31.7 points per game while allowing only 15.3 points per game en route to a 3-0 SU and ATS record.

Brady has already racked up eight touchdown passes and 1,004 passing yards with no interceptions this season, and has 12 touchdown passes to just one interception in his last four road games against Buffalo.

Under head coach Bill Belichick, New England has been masterful at getting revenge. The Patriots are 9-0 SU and 7-1-1 ATS in their last nine games after losing the previous game in a matchup.

Betting Line / Total: New England -6.5 / 47 Points

Trend: The Patriots are 11-1 SU and 9-2-1 ATS in their last 12 games on the road against the Bills.

Trend: The Bills are 8-3 ATS in their last 11 games after an ATS loss.

The Bills shook off an ugly 0-2 SU and ATS start to go 4-0 SU and ATS over their next four games, including upset wins over Arizona and New England and a road win against Los Angeles.

But after four straight double-digit wins, the Bills had a dud performance last week as a 2.5-point favorite in Miami, giving up 256 rushing yards in a 28-25 loss to the Dolphins. Buffalo is 6-0 SU and ATS in its last six games after losing as a favorite.

Sunday’s total is set at 47 points. The UNDER is 9-3 in Buffalo’s last 12 games played in Week 8 per the OddsShark NFL Database.

With a 6-1 SU and ATS record, New England already has a two-game lead over Buffalo in the AFC East. A road win for the Patriots this Sunday would put the team well on its way to another division title. The Patriots have won the AFC East in 12 of the last 13 seasons and in each of the last seven.

New England Patriots at Buffalo Bills

When: Sunday, October 30, 1:00 p.m. ET

Where: New Era Field, Buffalo, New York

Patriots at Bills OddsShark Matchup Report

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