Skip to main content
Come Fan with UsFriday, June 26, 2026

NFL odds 2016, Week 16: Opening betting lines and analysis for top matchups on the schedule

The Indianapolis Colts are road underdogs against the Oakland Raiders while the Green Bay Packers are home favorites against the Minnesota Vikings in Week 16 matchups.

Bruce Kluckhohn-USA TODAY Sports

The Indianapolis Colts are 4-0 straight up and 2-2 against the spread in their last four games against the Oakland Raiders. The Colts will try to extend their winning streak over the Raiders with a road win in Oakland this Saturday.

Indianapolis is a 4-point road underdog at sportsbooks monitored by OddsShark.com. This game will feature two of the best young quarterbacks in the NFL in Andrew Luck and Derek Carr leading two of the league’s top offenses. The Raiders rank third in the NFL with 26.9 points per game and the Colts aren’t far behind with 25.9 points per game.

While most of the games on the board have totals in the low 40s, this matchup sits at 53 points. The OVER is 6-2 in Oakland’s last eight games.

NFL Week 16 Betting Lines (see the complete list at OddsShark)

Detroit at Dallas (-7.5)

Minnesota at Green Bay (-6.5)

Baltimore at Pittsburgh (-5)

Denver at Kansas City (-4)

Indianapolis at Oakland (-4)

Only one game separates the 8-6 SU Green Bay Packers from the 7-7 Minnesota Vikings, but these two teams are trending in very different directions. Since starting the season on a 5-0 SU and ATS run, the Vikings are 2-7 SU and 3-6 ATS over their last nine games.

Green Bay, on the other hand, is 4-0 SU and 3-1 ATS over its last four games and is hoping to stay hot and earn a playoff spot down the stretch. The Packers are a 6.5-point favorite on the NFL lines over their division rivals at home this Saturday.

Two division rivalry games are scheduled on Christmas this Sunday with the Baltimore Ravens visiting the Pittsburgh Steelers (-5) in the afternoon and the Kansas City Chiefs (-4) hosting the Denver Broncos in the evening.

Baltimore is 0-7 SU and 1-6 ATS in its last seven late afternoon games. Denver is 6-1 ATS in its last seven road games against the Chiefs per the OddsShark NFL Database.

Rounding out Week 16, the Dallas Cowboys are a 7.5-point favorite at home against the Detroit Lions. Dallas has failed to cover the spread in each of its last four games since going a perfect 9-0 SU and ATS in its previous nine games. The Cowboys are just 3-10-1 ATS in their last 14 games at home against teams with winning records.

Sports Odds, Lines And Betting News
6 Super Bowl 60 prop bet picks for Seahawks vs. Patriots6 Super Bowl 60 prop bet picks for Seahawks vs. Patriots
Sports Odds, Lines And Betting News

There are some fun prop bets on the board for Super Bowl 60

By Bill Williamson
NFL
What Super Bowl odds tell us about the final four teamsWhat Super Bowl odds tell us about the final four teams
NFL

The Seahawks head into the conference championships as the Super Bowl 60 favorite. We break down the odds of the final four teams.

By David Fucillo
NFL
Opening odds for 49ers-Seahawks in 2026 NFC Divisional roundOpening odds for 49ers-Seahawks in 2026 NFC Divisional round
NFL

The NFC Divisional round is set. We break down the opening odds for 49ers-Seahawks.

By Nick Simon
Sports Odds, Lines And Betting News
Opening odds for Rams-Bears in 2026 NFC Divisional roundOpening odds for Rams-Bears in 2026 NFC Divisional round
Sports Odds, Lines And Betting News

The NFC Divisional round is set. We break down the opening odds for Rams-Bears.

By Nick Simon
Women's College Basketball
3 women’s college basketball teams with enticing 2026 national championship odds3 women’s college basketball teams with enticing 2026 national championship odds
Women's College Basketball

UConn and South Carolina are the favorites, but other women’s college basketball teams have enticing title odds.

By Mitchell Northam
Men's College Basketball
March Madness odds: Chances for every team in the 2025 NCAA tournament to win the titleMarch Madness odds: Chances for every team in the 2025 NCAA tournament to win the title
Men's College Basketball

Cooper Flagg leads Duke to be the tournament favorite.

By James Dator and David Fucillo