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Come Fan with UsMonday, June 29, 2026

NCAA Tournament Sweet 16 odds: Four No. 1 seeds all betting favorites

The March Madness field has been narrowed down to the Sweet 16, with all four No. 1 seeds still at the Big Dance and betting favorites this week.

Jeff Curry-USA TODAY Sports

The Wisconsin Badgers are 10-2 straight up and against the spread in their last 12 games against teams with winning records. Wisconsin will try to keep that betting trend going facing off against Notre Dame as we look at the Sweet 16 matchups.

Wisconsin is a 1-point betting underdog against No. 6 Notre Dame at sportsbooks monitored by OddsShark.com. The No. 7 Badgers are 13-3 SU and 12-4 ATS over their last 16 games.

Clashes between 6-seeds and 7-seeds are relatively rare, but in the last three instances, No. 7 seeds are 3-0 SU and ATS against No. 6 seeds.

For the first time since 2012, all four of the No. 1 seeds have advanced to the Sweet 16. No. 1 Kansas is a 6.5-point favorite against No. 5 Maryland.

The Jayhawks are 16-0 SU and 13-3 ATS in their last 16 games and 7-0 SU and 6-1 ATS in their last seven games as a favorite of seven points or less.

No. 5 Indiana is going off at +5.5 against No. 1 North Carolina, and is just 2-6 SU and ATS in its last eight games against ACC opponents.

No. 1 Oregon is going off as a 3-point favorite in its matchup with No. 4 Duke. The Ducks are 6-1 SU and 5-2 ATS in their last seven games with three days off between games, while Duke is 8-2 SU in its last 10 games in March.

No. 4 Iowa State is a 5-point underdog against No. 1 Virginia and is 0-6 SU in its last six games as an underdog. Virginia is 5-0 SU and ATS in its last five games as a favorite of 5.5 points or less per the OddsShark College Basketball Database.

In their last 28 games against No. 4 seeds, No. 1 seeds are 21-7 SU.

Rounding out the Sweet 16 schedule is No. 2 Villanova (-4) vs. No. 3 Miami, No. 2 Oklahoma (-2.5) vs. No. 3 Texas A&M, and No. 11 Gonzaga (-4.5) vs. No. 10 Notre Dame.

Miami is 7-3 SU and ATS in its last 10 games against Villanova and 6-2 SU and ATS in its last eight games against Big East opponents.

Syracuse is 1-4 SU and 0-5 ATS in its last five games with four days of rest between games and 0-5 SU in its last five games as an underdog.

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