Skip to main content
Come Fan with UsSunday, June 28, 2026

NFL odds and lines, Week 1: Broncos, Cowboys, Saints games highlight opening betting slate

The Denver Broncos, Dallas Cowboys and New Orleans Saints will all be facing tough tests at home this week as the NFL betting slate gets started.

Mark J. Rebilas-USA TODAY Sports

The Denver Broncos are 10-1 straight up and 7-4 against the spread in their last 11 games played in the month of September. The defending Super Bowl champions will try to keep that successful trend going at home against the Carolina Panthers on Thursday night.

Denver is a three-point home underdog in Thursday night’s Super Bowl rematch at sportsbooks monitored by OddsShark.com. The Broncos are 25-4 SU in their last 29 games at home, but bettors seem to believe that starting an inexperienced quarterback in Trevor Siemian against a team of Carolina’s caliber might be too much to overcome.

The Panthers are 1-4 SU and 2-3 ATS in their last five games against the Broncos.

Another inexperienced quarterback looking to lead his team to victory at home on Sunday is rookie Dak Prescott, who will start for the Dallas Cowboys in place of injured starter Tony Romo. Dallas was originally a 3.5-point favorite at home against the New York Giants in the weeks leading up to this game, but Romo's injury has bumped this game down to a pick'em.

The Giants have been perennial slow starters of late with an 0-5 SU and 1-4 ATS record in their last five season-opening games.

There will be no lack of experience at quarterback in New Orleans when Drew Brees takes the field as a one-point favorite at home against the Oakland Raiders. Oakland seemed to be heading in the right direction last season with a 7-9 SU and 8-8 ATS campaign, and have become a popular dark horse pick to make the postseason this year after making a big splash in free agency.

But value could be on the home team in this one as the Raiders are 1-12 SU in their last 13 Week 1 games and 2-6 SU and 1-7 ATS in their last eight games against the Saints per the OddsShark NFL Database.

The first week of the NFL regular season wraps up with New England at Arizona (minus-6) on Sunday night and a double-header on Monday night featuring Pittsburgh (minus-3) at Washington and Los Angeles (minus-2.5) at San Francisco. Jimmy Garoppolo will start in place of the suspended Tom Brady for New England on Sunday.

NFL Week 1 Betting Lines

New England at Arizona (-6)

Carolina (-3) at Denver

Pittsburgh (-3) at Washington

Los Angeles (-2.5) at San Francisco

Oakland at New Orleans (-1)

NY Giants at Dallas (Pick’em)

Sports Odds, Lines And Betting News
6 Super Bowl 60 prop bet picks for Seahawks vs. Patriots6 Super Bowl 60 prop bet picks for Seahawks vs. Patriots
Sports Odds, Lines And Betting News

There are some fun prop bets on the board for Super Bowl 60

By Bill Williamson
NFL
What Super Bowl odds tell us about the final four teamsWhat Super Bowl odds tell us about the final four teams
NFL

The Seahawks head into the conference championships as the Super Bowl 60 favorite. We break down the odds of the final four teams.

By David Fucillo
NFL
Opening odds for 49ers-Seahawks in 2026 NFC Divisional roundOpening odds for 49ers-Seahawks in 2026 NFC Divisional round
NFL

The NFC Divisional round is set. We break down the opening odds for 49ers-Seahawks.

By Nick Simon
Sports Odds, Lines And Betting News
Opening odds for Rams-Bears in 2026 NFC Divisional roundOpening odds for Rams-Bears in 2026 NFC Divisional round
Sports Odds, Lines And Betting News

The NFC Divisional round is set. We break down the opening odds for Rams-Bears.

By Nick Simon
Women's College Basketball
3 women’s college basketball teams with enticing 2026 national championship odds3 women’s college basketball teams with enticing 2026 national championship odds
Women's College Basketball

UConn and South Carolina are the favorites, but other women’s college basketball teams have enticing title odds.

By Mitchell Northam
Men's College Basketball
March Madness odds: Chances for every team in the 2025 NCAA tournament to win the titleMarch Madness odds: Chances for every team in the 2025 NCAA tournament to win the title
Men's College Basketball

Cooper Flagg leads Duke to be the tournament favorite.

By James Dator and David Fucillo