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Come Fan with UsThursday, June 25, 2026

NFL odds 2017, Week 10: Betting lines, trends, and analysis for the week’s top games

The Niners are rare betting favorites as they face the Giants, while the Saints are road chalk in Buffalo riding a winning streak.

NFL: Tampa Bay Buccaneers at New Orleans Saints
NFL: Tampa Bay Buccaneers at New Orleans Saints
Chuck Cook-USA TODAY Sports

The San Francisco 49ers are 0-9 straight up and 4-5 against the spread so far this season. The 49ers will have their best remaining chance at a win this season on Sunday when they host the New York Giants.

San Francisco is a 1.5-point home favorite at sportsbooks monitored by OddsShark.com. If the line doesn’t move against them, this will be the 49ers’ first game as a betting favorite in 2017. The team is 1-6 SU and 0-7 ATS in its last seven games as a favorite. New York is 9-3 SU and ATS in its last 12 road games after consecutive games at home. These two teams and the winless Cleveland Browns are in the running for the top pick in the 2018 NFL draft.

NFL Week 10 Odds

Miami at Carolina (-9)

New England (-7.5) at Denver

Seattle (-5.5) at Arizona

Dallas at Atlanta (-3)

New Orleans (-2) at Buffalo

NY Giants at San Francisco (-1.5)

See the complete list at OddsShark

While the Giants and 49ers try to snap their losing streaks, the New Orleans Saints will be trying to extend their winning streak. The Saints are 6-0 SU and 5-1 ATS over their last six games since starting the season off 0-2 SU and ATS.

New Orleans is 4-0 SU and ATS in its last four games against Buffalo and is a 2-point road favorite against the Bills on Sunday.

The status of Ezekiel Elliott continues to remain in flux, but the Cowboys keep winning with him in the lineup going 3-0 SU and ATS over their last three games. Dallas is currently a three-point underdog on the road against the Atlanta Falcons for Sunday, but that line may change when Elliott’s status becomes more clear later in the week.

The Cowboys are 8-3 SU and ATS in their last 11 games played in Week 10 per the OddsShark NFL Database.

In primetime this week, the Seattle Seahawks kick off Week 10 as 5.5-point road favorites on Thursday Night Football against the Arizona Cardinals. New England is a 7.5-point road favorite on Sunday Night Football against the Denver Broncos, and the Carolina Panthers are 9-point favorites at home against the Miami Dolphins on Monday Night Football.

Miami is 4-1 SU and 5-0 ATS in its last five games against the Panthers but just 1-10 SU in their last 11 road games against teams with winning records.

For more info, picks and a breakdown of this week’s top sports betting news check out the new OddsShark podcast with Jon Campbell and Andrew Avery. Subscribe on iTunes, or check it out at OddsShark.libsyn.com.

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