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Come Fan with UsTuesday, June 23, 2026

NCAA tournament odds 2018: Betting lines and trends for Friday’s Sweet 16 games

The last two No. 1 seeds remaining in the NCAA tournament will try to advance to the Elite Eight as betting favorites at the sportsbooks Friday night.

NCAA Basketball: Big 12 Conference Tournament Championship-West Virginia vs Kansas
NCAA Basketball: Big 12 Conference Tournament Championship-West Virginia vs Kansas
William Purnell-USA TODAY Sports

The No. 1 Kansas Jayhawks are 10-1 straight up and 7-4 against the spread over their last 11 games, including a current stretch of 5-0 SU and 4-1 ATS. The Jayhawks will try to keep rolling when they take on the No. 5 Clemson Tigers in the first game of Friday’s Sweet 16 action.

Kansas is a 4.5-point betting favorite over the Tigers at sportsbooks monitored by OddsShark.com. The week off after the Round of 32 was great for the Jayhawks, who are trying to nurse their 7-foot sophomore center Udoka Azubuike back to good health. Azubuike had 10 points in 22 minutes of play coming off a knee injury in Kansas’ 83-79 win over Seton Hall.

The Jayhawks are 7-0 SU in their last seven games against ACC teams while Clemson is 0-4 SU and ATS in its last four games against Big 12 opponents.

No. 1 Villanova is 7-0 SU over its last seven games and 5-1 ATS over its last six, cruising through the tournament so far with an 87-61 win over Radford and an 81-58 win over Alabama. The Wildcats are 5.5-point favorites facing West Virginia Friday.

The No. 5 Mountaineers have also been on fire through the first two rounds with an 85-68 win over Murray State and a 94-71 win over Marshall. Historically, Villanova has dominated in Friday games with a 19-0 SU record in its last 19 games played on a Friday.

Despite the fact there are still two No. 1 seeds remaining in the tournament, the No. 2 Duke Blue Devils are the current favorite on the odds to win the national championship at +325. Duke is 9-2 SU and ATS in its last 11 games and is going off as an 11.5-point favorite on Friday against the No. 11 Syracuse Orange. Syracuse has pulled off three straight upsets to get to this point including a 55-53 win as 10-point underdogs over Michigan State on Sunday.

The Sweet 16 wraps up with what figures to be a highly competitive game between the No. 2 Purdue Boilermakers (-1.5) and the No. 3 Texas Tech Red Raiders. Texas Tech is 8-2 SU and 7-2-1 ATS in its last 10 games against Big Ten opponents per the OddsShark College Basketball Database.

March Madness Sweet 16 Odds

Duke (-11.5) vs. Syracuse

Kansas (-4.5) vs. Clemson

Villanova (-5.5) vs. West Virginia

Purdue (-1.5) vs. Texas Tech

For more odds information, betting picks, and a breakdown of this week’s top sports betting news check out the OddsShark podcast with Jon Campbell and Andrew Avery. Subscribe on iTunes or listen to it at OddsShark.libsyn.com.

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