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Come Fan with UsSunday, June 21, 2026

Yankees betting favorites vs. Red Sox in Friday series opener

The New York Yankees visit the Boston Red Sox in the final series of the regular season for these rivals, with the sportsbooks siding with the road club in the opener.

MLB: New York Yankees at Tampa Bay Rays
MLB: New York Yankees at Tampa Bay Rays
Kim Klement-USA TODAY Sports

The New York Yankees are 7-3 over their last 10 games including a 2-1 record in their last three-game series against the Boston Red Sox. The Yankees will try to wrap up the regular season with another series win over the Red Sox in a three-game set starting on the road this Friday night.

New York is a -120 road favorite on Friday night at sportsbooks monitored by OddsShark.com. J.A. Happ takes the mound for the Yankees going up against Brian Johnson and the Red Sox as +110 home underdogs.

Boston Red Sox at New York Yankees

When: Friday, September 28, 7:10 p.m. ET

Where: Fenway Park, Boston, Massachussetts

Betting Line / Total: New York -120 / 9 Runs

Yankees at Red Sox OddsShark Matchup Report

New York Yankees

Led by Giancarlo Stanton who hit his 36th and 37th home runs of the season, the Yankees hit four bombs in total in their 12-1 win over the Tampa Bay Rays on Thursday afternoon.

New York has hit 260 home runs this season and enters this series against the Red Sox just four short of the all-time single-season record of 264 home runs set by the Seattle Mariners in 1997.

Whether this team breaks the record or not this weekend, there’s no question that this will be a lethal lineup for opposing teams to deal with this postseason.

J.A. Happ has been masterful for the Yankees with a 2.34 ERA and a 1.06 WHIP through 10 starts, leading the team to an 8-2 record in those 10 games per the OddsShark MLB Database. Happ is projected to start in New York’s wild card matchup against Oakland next week.

Boston Red Sox

This Boston squad has nothing left to prove during the regular season, running away with the best record in baseball and setting a new franchise record in wins with a record of 107-52. While the Red Sox would love to enter the playoffs with some momentum, the top priority this weekend is to keep everyone healthy. Boston is 4-1 in five games as a home underdog this season.

Friday night’s total is set at nine runs. The OVER is 5-3-1 in the last nine games between New York and Boston.

Should the Yankees win their wild card matchup against Oakland, they would find themselves right back at Fenway Park for the ALDS. This weekend’s action wraps up with projected pitching matchups of Lance Lynn vs. Nathan Eovaldi on Saturday and Luis Severino vs. Rick Porcello on Sunday.

For more odds information, betting picks and a breakdown of this week’s top sports betting news check out the OddsShark podcast with Jon Campbell and Andrew Avery. Subscribe on iTunes or listen to it at OddsShark.libsyn.com.

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