Skip to main content
Come Fan with UsSunday, June 21, 2026

NFL odds, Week 13: 49ers vs. Rams

The 49ers open as 8-point favorites over the Rams, the team they tied in Week 10.

Brian Bahr

When they squared off back in Week 10, the 49ers and Rams became historical footnotes, battling to a 24-24 tie. San Francisco entered that game at Candlestick as a 13.5-point favorite, but the Rams have played better since. The spread this week is 8, with the Rams hosting the 49ers in the Edward Jones Dome.

The 49ers have been reliable cover artists, going 7-4 against the spread and coming off victories against New Orleans and Chicago. New quarterback Colin Kaepernick has been a spark plug for the offense, who have topped 30 point in each of his starts. The defense remains astounding, allowing a league-best 14.1 points per game to opponents. Their two return touchdowns last week against the Saints appear to be the rule rather than the exception.

The Rams have looked lost at times, such as their Week 11 defeat at the hands of the Jets. But a 31-17 victory over Arizona on Sunday gave St. Louis something to hang their hats on. Also, their 7-3 record against the spread as underdogs is pretty impressive. The Rams have been 8 or more point underdogs twice this season and have covered both times, including the Week 10 tie against the 49ers.

For all of the odds on this week's NFL games and all kinds of other sports, check out Odds Shark. SB Nation also has all of the Week 13 NFL Odds. For more on the 49ers, head over to Niners Nation. For more on the Rams, check out Turf Show Times.

See More:

More in General

GeneralFromPosting and Toasting
An SB Nation New Yorker needs our helpAn SB Nation New Yorker needs our help
GeneralFromPosting and Toasting
General
Sabastian Sawe breaks 2-hour barrier, shatters marathon world recordSabastian Sawe breaks 2-hour barrier, shatters marathon world record
General

The mythical two-hour mark was broken at the London Marathon.

By Bernd Buchmasser
A Huge Dog
THE HISTORY OF CHARGING THE MOUND, EPISODE 1THE HISTORY OF CHARGING THE MOUND, EPISODE 1
Play
General
Super Bowl 60 coin toss resultsSuper Bowl 60 coin toss results
General

The Seahawks and Patriots will open the Super Bowl with the coin toss to determine who starts with the ball. We have the full coin toss results for Super Bowl 60.

By David Fucillo
General
Marc Marquez completes a comeback for the agesMarc Marquez completes a comeback for the ages
General

MotoGP’s Marc Marquez completed a comeback for the ages with his 2025 title

By Mark Schofield
General
How to make sure SBNation.com appears in your Google search resultsHow to make sure SBNation.com appears in your Google search results