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Come Fan with UsMonday, June 22, 2026

NFL Picks And Predictions: Rams Vs. Lions

NFL expert picks for the Week 1 matchup between the Detroit Lions and St. Louis Rams.

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The St. Louis Rams and the Detroit Lions will meet in Detroit Sunday during Week 1 of the NFL regular season, and experts agree that Calvin Johnson and the Lions are a lock to win.

The 14-member panel at ESPN.com has unanimously selected Detroit to win, as have all nine expert sources at CBSSports.com and the three-man panel at Yahoo! Sports.

It would be a big upset if Jeff Fisher and the Rams could open up with a win, but crazier things have happened in the NFL.

For a complete look at the matchup from the perspective of oddsmakers, be sure to check out our related Week 1 NFL odds post.

Be sure to visit Pride of Detroit for more Lions coverage, and head over to Turf Show Times for more on the Rams. Also visit SB Nation’s NFL hub for even more news and analysis from around the league.

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