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Come Fan with UsFriday, June 26, 2026

Week 10 college football opening lines: Florida State, Georgia, Michigan State favored

College football’s opening odds for Week 10 are out, with some big matchups expected to be tight contests -- with one notable exception.

Jeff Gammons

The opening lines have been released for what should be another action-packed week in college football, even with Alabama, Oregon and Baylor all on byes.

The biggest favorite is Texas A&M, who opens -45.5 against UTEP. The game with the tightest margin expected? USC at Oregon State, where the Beavers are two-point favorites.

Some other notable lines -- Georgia is a slight favorite vs. Florida, Michigan State is favored by a little more than a field goal over Michigan, and Oklahoma State is favored at newly defeated Texas Tech. In a top ten matchup, Florida State is favored by 21 points hosting Miami.

For updates throughout the week, head over to OddsShark.

  • Cincinnati (-3) at Memphis
  • South Florida at Houston (-10.5)
  • Louisiana-Monroe at Troy (-3)
  • Rice at North Texas (-2.5)
  • Arizona State (-13.5) at Washington State
  • USC at Oregon State (-2)
  • Temple at Rutgers (-14)
  • Virginia Tech (-6) at Boston College
  • Northern Illinois (-24) at Massachusetts
  • Ohio State (-31) at Purdue
  • Southern Miss at Marshall (-28.5)
  • Illinois at Penn State (-10)
  • Wisconsin (-7) at Iowa
  • Mississippi State at South Carolina (-11.5)
  • North Carolina (-3) at North Carolina State
  • Wake Forest at Syracuse (-3.5)
  • Western Kentucky (-19) at Georgia State
  • Middle Tennessee State (-6) at UAB
  • Minnesota at Indiana (-7)
  • Clemson (-20) at Virginia
  • Kent State (-2.5) at Akron
  • Georgia (-2.5) vs. Florida
  • Arizona (-14.5) at California
  • Iowa at Kansas State (-14.5)
  • Northwestern at Nebraska (-7)
  • West Virginia at TCU (-14)
  • UTSA at Tulsa (-3.5)
  • Kansas at Texas (-27)
  • Navy at Notre Dame (-17)
  • Michigan at Michigan State (-3.5)
  • Tennessee at Missouri (-13)
  • Hawaii at Utah State (-21)
  • San Jose State (-2.5) at UNLV
  • New Mexico State at Louisiana-Lafayette (-27)
  • Tulane at Florida Atlantic (-3)
  • Texas State (-13) at Idaho
  • East Carolina (-20) at Florida International
  • Pittsburgh at Georgia Tech (-8)
  • Oklahoma State (-2.5) at Texas Tech
  • Eastern Michigan at Toledo (-28)
  • Colorado at UCLA (-24)
  • Arkansas State at South Alabama (-2.5)
  • Miami at Florida State (-21)
  • Boise State (-10) at Colorado State
  • New Mexico at San Diego State (-17)
  • UTEP at Texas A&M (-45.5)
  • Nevada at Fresno State (-23)

More from SB Nation college football:

All of Week 9’s scores, with game recaps

BCS projections: Oregon likely jumping FSU for No. 2

SEC thriller in World Series country: Steven Godfrey at South Carolina-Mizzou

New bowl projections: Alabama-Oregon, and A&M to BCS?

You have to see what Ohio State’s band did

Alabama, Oregon, FSU top new human polls

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