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Come Fan with UsTuesday, August 4, 2026

Florida State at Louisville betting odds guide and prediction

Florida State hopes to remain undefeated visiting the Louisville Cardinals this Thursday night.

The Louisville Cardinals are 8-0 SU and 6-2 ATS in their last eight home games against ACC opponents. The Cardinals hope to add to that win streak with an upset over the Florida State Seminoles this Thursday night. Florida State visits Louisville at 7:30 p.m. ET Thursday (ESPN) at Papa John's Cardinal Stadium.

Louisville is a 4.5-point home underdog at sportsbooks monitored by OddsShark.com. Florida State’s tight rope act could come back to haunt the Seminoles at some point, but at only -4.5 Florida State still looks like the pick in this one.

The Cardinals have put together a solid season in the ACC to this point with a 6-2 SU and 5-3 ATS record. As was the case under former head coach Charlie Strong, Louisville’s strength lies in its defense, which ranks fourth in the country allowing only 14.6 points per game. The defense will need to be at its best to keep Jameis Winston and company in check this Thursday night. Louisville is just 1-7 SU and ATS in its last eight games as a home underdog.

OddsShark Computer Prediction: Florida State 37.3, Louisville 25.2

Off-field issues continue to plague the Florida State Seminoles as reports came out this week that the team’s leading rusher, Karlos Williams, is being investigated in a domestic abuse incident. With a 1-7 ATS record over its last eight games, Florida State hasn’t been earning any style points with its undefeated record, but the team keeps finding ways to win and ways to play through adversity. The Seminoles are just 4-8 ATS in their last 12 games as a road favorite.

The OVER is 8-0 in Florida State’s last eight road games against ACC opponents. That trend could change this week going up against one of the nation’s best defenses, but Florida State has averaged 37.9 points per game and has scored at least 31 points in every game that Jameis Winston has started. The Seminoles should be able to do enough on offense to squeak out a road win as a 4.5-point favorite at sportsbooks monitored by OddsShark.com.

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