The Ohio State Buckeyes are 2-0 straight up and against the spread in their last two games with back-to-back 62-3 wins. The Buckeyes will look to post up another blowout win this Saturday when they visit the Michigan State Spartans.
College football odds and lines, Week 12: More big favorites after Upset Weekend
Ohio State, Clemson, and Louisville will try to survive road tests and avoid a second loss this week in highlight games on the college football odds board.
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Ohio State is a 21.5-point road favorite at sportsbooks monitored by OddsShark.com. After losing to Michigan State 17-14 at home last season, the Buckeyes should be fired up to get some revenge this week, and Ohio State is 15-4 ATS in its last 19 games after losing to a team in the previous game of a matchup.
Michigan State is just 2-5 ATS in its last seven games against Big Ten opponents.
College Football Week 12 Betting Lines (see the complete list at OddsShark)
Buffalo at Western Michigan (-34.5)
UNLV at Boise State (-26.5)
Indiana at Michigan (-26)
Clemson (-21.5) at Wake Forest
Ohio State (-21.5) at Michigan State
Florida at LSU (-14)
USC (-10.5) at UCLA
Oklahoma State at TCU (-4)
Oklahoma (-3) at West Virginia
Washington State at Colorado (-3.5)
The Clemson Tigers had a 15-game conference win streak snapped on Saturday in a shocking 43-42 loss at home to Pittsburgh as a 21.5-point favorite. With their margin for error now erased, the Tigers will try to avoid another upset as a 21.5-point road favorite against the Wake Forest Demon Deacons.
The Tigers are 2-6 ATS in their last eight games as a favorite of 20 points or more. Wake Forest is 2-8 SU and 3-7 ATS in its last 10 games played in Week 12.
Louisville’s stock might have risen after three of the top four teams in the country took their first losses of the season last week, but the Cardinals still need to win out to keep their hopes alive. On Thursday night, the Cardinals face a tough test on the road against the Houston Cougars.
The Cardinals are 6-2 SU in their last eight games against the Cougars, but the head-to-head series is knotted up at 4-4 ATS over that stretch per the OddsShark College Football Database.
The Michigan Wolverines had an air of invincibility about them heading into last Saturday, but that is now gone after a 14-13 road loss to Iowa as a 24-point favorite. With a season-defining game against Ohio State looming two weeks away, the Wolverines will try to get back on track as a 26-point home favorite against the Indiana Hoosiers on Saturday.
Michigan has won each of its last 15 games against the Hoosiers and is 6-2 ATS in its last eight games coming off a loss.
