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Come Fan with UsMonday, June 22, 2026

C.J. Spiller injury update: Questionable but should be available for fantasy owners

Buffafo Bills running back C.J. Spiller (ankle) participated in practice on Friday and is listed as questionable in Week 6. We break down the fantasy football implications.

Rick Stewart

Buffalo Bills running back C.J. Spiller (ankle) participated in practice on Friday and is questionable against the Bengals in Week 6. Spiller is dealing with an ankle injury and was limited in practice on Wednesday and Thursday.

Fantasy Impact: Spiller is expected to play on Sunday and figures to see plenty of carries along with Fred Jackson. With first-round rookie quarterback E.J. Manuel (sprained LCL) out again, the Bills will start Thad Lewis. With only one NFL start under his belt, it stands to reason that Buffalo will go with a run-heavy offense.

Even with Fred Jackson playing at a high level, fantasy owners can still expect Spiller to receive 15-20 carries. However, the former top-ten draft pick has not yet lived up to his first round ADP this year. He has only hit the century mark once, during Week 2 against Carolina, and his sole touchdown came on a 54-yard rush. Jackson should continue to see the goal line carries, which puts Spiller at a low-end RB2/FLEX play. With only nine catches on the year, Spiller can not be seen as a PPR asset.

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