Skip to main content
Come Fan with UsFriday, August 7, 2026

Fantasy football waiver wire: 5 running backs to target for Week 16

Which running backs should you target in the final week of fantasy football?

NFL: Baltimore Ravens at New England Patriots
NFL: Baltimore Ravens at New England Patriots
Stew Milne-USA TODAY Sports

The moment of truth has arrived. Week 16 marks the championship round in fantasy football (unless you’re in one of those weird leagues that plays into Week 17), and if you’re still alive, congratulations. Lineup decisions will be more important than ever with fantasy glory just within your grasp.

The waiver wire doesn’t have as much importance at this time of year compared to the bye weeks, but fantasy owners could still stand to shore up their roster depth. In addition, dynasty/keeper league owners might want to start looking ahead to 2017 and stash potential breakout players for next year. With that in mind, here are the top waiver options at running back for Week 16, owned in less than 50 percent of Yahoo! standard leagues.

Kenneth Dixon, Baltimore Ravens (49 percent)

It looked like Dixon won the backfield competition for good after putting up 81 total yards against the New England Patriots. Instead, Terrance West once again saw more touches than Dixon last week. The rookie was held to nine carries for 36 yards, and was strangely invisible in the passing game with just one target. The good news is that he scored another touchdown, but Dixon is a risky flex play against the Pittsburgh Steelers this week.

Dion Lewis, New England Patriots (48 percent)

Finally unleashed after missing most of the year with a knee injury, Lewis turned 20 touches into 104 total yards against the Ravens. It was an especially surprising performance with the Ravens boasting one of the best run defenses in football. Of course, LeGarrette Blount still vultured a goal line touchdown and James White remains a factor on passing downs. The Patriots’ backfield is impossible to predict from week to week, so Lewis is a pretty big gamble. He does have a good matchup with a checked-out New York Jets team this week.

Derrick Henry, Tennessee Titans (45 percent)

DeMarco Murray continues to dominate touches in the Titans’ backfield, but Henry is still doing a lot with limited action. He played a key role in Tennessee’s comeback win over the Kansas City Chiefs, rushing for 58 yards and two touchdowns on nine carries. Seeing more playing time in recent weeks, Henry is an appealing flex option against the Jacksonville Jaguars this week.

Mike Gillislee, Buffalo Bills (25 percent)

If you like touchdown vultures, you’ll love Gillislee. He got another one on Sunday, his seventh of the season. Gillislee doesn’t have much standalone value with LeSean McCoy dominating, but goal line carries are enough to keep him on the RB3 radar. The Bills take on the Miami Dolphins next.

Paul Perkins, New York Giants (13 percent)

The Giants are stubbornly sticking with an RB committee even though it hasn’t been that effective. In the past two games, Rashad Jennings has 33 carries for just 83 yards, while Perkins has 26 carries for 101 yards. The rookie probably won’t do enough to earn fantasy value this season, but he’s a good dynasty stash for 2017 with Jennings getting up there in years (he turns 32 in March).

NFL
Best DFS picks for Cardinals vs Panthers in Hall of Fame GameBest DFS picks for Cardinals vs Panthers in Hall of Fame Game
NFL

Nick Simon brings you his favorite picks for FanDuel’s Thursday night preseason battle.

By Nick Simon
NFL
Stefon Diggs fantasy football outlook: What Commanders signing means for 2026Stefon Diggs fantasy football outlook: What Commanders signing means for 2026
NFL

Can Stefon Diggs help your fantasy team this year?

By Mark Schofield
NFL
The most impactful injuries from NFL training camp so farThe most impactful injuries from NFL training camp so far
NFL

Tracking the big injuries so far.

By James Dator
NFL
NFL starting QBs ranked by analytics before 2026 seasonNFL starting QBs ranked by analytics before 2026 season
NFL

Breaking down every QB by overall rating and tier.

By James Dator
NFL
Best DFS picks for Patriots vs Texans in Divisional roundBest DFS picks for Patriots vs Texans in Divisional round
NFL

Chet Gresham takes us through his favorite picks for FanDuel’s Divisional round DFS matchup between the Patriots and Texans

By Chet Gresham
NFL
Best DFS picks for Bears vs Rams in Divisional roundBest DFS picks for Bears vs Rams in Divisional round
NFL

Chet Gresham takes us through his favorite picks for FanDuel’s Divisional round DFS matchup between the Bears and Rams

By Chet Gresham