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Come Fan with UsThursday, August 6, 2026

Kyler Murray injury: Arizona QB’s status uncertain ahead of Cardinals-Colts

The Cardinals may be without Kyler Murray this weekend against the Indianapolis Colts

NFL: Tennessee Titans at Arizona Cardinals
NFL: Tennessee Titans at Arizona Cardinals
Joe Camporeale-Imagn Images
Mark Schofield
Mark Schofield is a former college quarterback and attorney covering the NFL and F1.

Update (Saturday): While the Cardinals are leaving the door open for Kyler Murray to play on Sunday, the team is expected to start Jacoby Brissett against the Indianapolis Colts.

Murray has, according to Ian Rapoport, suffered a “version” of a Lisfranc mid-foot sprain, and there is a possibility that Murray will be sidelined for more than a week.

Update (Friday): Cardinals head coach Jonathan Gannon indicated that while Kyler Murray is returning to practice today, his status for Sunday’s game will be determined over the next few days.

Last Sunday was a disaster for the Arizona Cardinals. Three baffling moments in the fourth quarter -- running back Emari Demercado fumbling just short of the goalline to take a long TD run off the board, a shotgun snap bouncing off Kyler Murray’s face for a fumble, and an interception being fumbled and turning into a Tennessee Titans’ touchdown -- helped gift Tennessee a comeback win.

Now the Cardinals have to worry about the health of their quarterback.

Kyler Murray, who left Sunday’s win with a foot injury before returning to action, is not expected to practice on Wednesday as he recovers from the injury. Arizona takes on the surprising Indianapolis Colts on Sunday on the road, as they look to bounce back from Sunday’s debacle and even their record at 3-3.

Jacoby Brissett, who threw an incompletion on his only passing attempt when he came on for a few plays Sunday as Murray was evaluated, is Arizona’s backup quarterback.

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