Jacoby Brissett start or sit: Week 10 fantasy football advice

Week 10 of the 2025 NFL season rolls on and the action will continue this afternoon with an NFC West showdown featuring the Arizona Cardinals visiting the Seattle Seahawks at 4:05 p.m. ET on CBS.

The Cardinals finally ended their five-game losing streak last Monday night, upending the Cowboys in a 27-17 victory. Quarterback Jacoby Brissett once again filled in for Kyler Murray as the starter and he’ll be retaining that role moving forward as the Cards try climb their way back into the NFC playoff hunt.

Below, we’ll go over Brissett’s outlook in fantasy football for Week 10.

Brissett had a very good night against the Cowboys last Monday, throwing for 261 passing yards with through the air and added an additional rushing touchdown on the ground for good measure. The Cardinals’ offense has looked better since Brissett first stepped in for an injured Murray back in Week 6 and that immediately led to speculation if the veteran journeyman would unseat the former No. 1 overall pick. After Monday’s win, head coach Jonathan Gannon interestingly enough said that Brissett would be the starter for this week even if Murray were 100 percent healthy.

The veteran QB has certainly stepped up on the fantasy football front as he’s been a top-12 fantasy QB in each of his three starts for Arizona. The small numbers of fantasy managers who actually started Brissett last week were rewarded with 24.8 points and I expect him to become a hot waiver wire commodity if he delivers another solid performance this afternoon.

Start. If you were one of the managers who did pick Brissett up a few weeks ago, keep riding the hot hand. The Cardinals have some momentum right now and the veteran may have outright jacked the starting job from Murray for the rest of the season. Give him another start.