NFL Expert Picks for Week 10 of 2025

With just over half the season gone we’re now into the mad rush to the finish. A lot has been made of the parity in the NFL, and it’s stunning to see all 32 teams are still technically in contention — and realistically we have as many as 24 teams who could still make the playoffs based on how these final games play out.

The big story as we enter Week 10 are injuries. The league is absolutely riddled with that, and that could define the back-end to the season. In Green Bay the Packers will need to adjust to like without Tucker Kraft, who tore his ACL in Week 9. The Commanders’ season is effectively done with Jayden Daniels’ dislocated elbow. Then we sprinkle in some temporary intrigue with a team like Tampa Bay, who are still reeling with the loss of Mike Evans, but in Week 10 also have to contend with Bucky Irving, Chris Godwin, and Haason Reddick all being banged up — potentially missing a key game against the Patriots.

In short: It’s anyone’s season, and it’s impossible to predict what will happen in the NFL each week — just ask the Vikings and Panthers, who beat the Lions and Packers respectively.

Here are our picks in Week 10.