Jameson Williams start or sit: Week 10 fantasy football advice

Week 10 of the 2025 NFL season rolls on and the action will continue this afternoon with a rematch of last year’s NFC Divisional round featuring the Detroit Lions visiting the Washington Commanders at 4:25 p.m. ET on FOX.

The Lions have dropped two of their last three contests and came up short last Sunday, falling to the Vikings 27-24 in a midseason divisional showdown. Wide receiver Jameson Williams at least made an impact and they’ll need him to step up again this afternoon.

Below, we’ll go over Williams’ outlook in fantasy football for Week 10.

Williams caught four of six targets for 66 yards and a fourth quarter touchdown that brought the Lions to within three late in last week’s ballgame. The fourth-year wideout has been up and down as a fantasy asset this season and that’s especially been the case over the last month, one week being a ghost in the offense only to come back as a primary contributor the following week.

Fortunately, he’ll be matched up against one of the worst pass defenses in the league at the midway point of the regular season. The Commanders are bottom-five in defensive passing EPA, giving up the second-most passing yards in the league at 2,417 along with 19 passing touchdowns.

Start. The Lions have typically laid the hammer down following losses under Dan Campbell and I expect no different in this week’s matchup against the Commanders. Washington’s pass defense in particular is a weakness that I expect them to aggressively attack and that could mean a big day for Jamo. Start him.

Start.