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Come Fan with UsThursday, June 25, 2026

NFL Week 10 Picks: St. Louis Rams Vs. San Francisco 49ers

The St. Louis Rams will meet the San Francisco 49ers in Week 10 in a game that surprisingly may mean something in the NFC West. The 49ers were off to a terrible start this season but, thanks to the NFC West, stand only two games out of first place. One of those teams in first place is the Rams sporting a 4-4 record after winning just one game in 2009.

The 49ers enter the game with Troy Smith at QB. He's coming off of a decent performance against the Broncos in a Week 8 victory. The 49ers biggest threat is Frank Gore. The offense seems to move much better when he's playing well so I imagine that remains the priority. The Rams are relatively strong stopping the run so that will be a matchup to watch.

The Rams offense, like the 49ers, is slanted a little to the running back, Steven Jackson. But people have been impressed with Sam Bradford, whose averaging a little over 200 yards per game and has 11 TDs and eight interceptions on the season.

The 49ers are six point favorites at home, which is a little surprising if you look at how they started the season. They’ve been rebounding in recent weeks. I’m taking the 49ers but by less than six points.

Your SB Nation blogs for this game are Turf Show Times and Niners Nation.

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