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Come Fan with UsMonday, June 22, 2026

NFL Odds And Lines Week 15: Steelers Vs. 49ers

The San Francisco 49ers, already secure in a playoff spot, lost to the Arizona Cardinals last week. Will they be able to beat the Pittsburgh Steelers?

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The San Francisco 49ers locked up the NFC West title a couple of weeks ago, but they were unable to overcome the Arizona Cardinals last Sunday., losing a 21-19 game. If the Cardinals proved a surprising matchup in that game, this Sunday's game against the Pittsburgh Steelers will be an early playoff test. The 49ers are 2.5 point favorites over the Pittsburgh Steelers on Monday Night Football, according to Odds Shark.

An over/under for this game has yet to be set, but it probably won’t be too high. The Niners and the Steelers are Nos. 1 and 2, respectively, in point allowed at 14.0 and 15.2. This could certainly turn into one of the better regular season battle.

Check out Odds Shark for more Week 15 NFL odds and line. To learn more about this game, visit Steelers blog Behind the Steel Curtain and 49ers blog Niners Nation. Move over to SB Nation NFL to keep up with the rest of the league.

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