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Come Fan with UsMonday, June 22, 2026

NFL Picks, Week 16: Computer Odds Favor The Underdogs On Christmas Eve

It’s Week 16, and after one of the wildest weeks in recent memory, the playoff race in both conferences is heating up. Take a look at the odds to see who might pull of an upset on Christmas Eve. All content comes courtesy of SB Nation’s odds partners at Odds Shark.

On the heels of a wild week where the 13-0 team lost and the 0-13 team won, anything should be expected in Week 16 NFL wagering. But the Odds Shark scores computer is siding generously with road underdogs in its Week 16 picks roundup.

The Packers, Steelers, Patriots and Ravens were all double-digit home favorites this week but the computer only likes one team (Pittsburgh) to cover the spread. That would make ATS winners of the Bears, Dolphins and Browns for everyone keeping track at home.

The engine also predicts outright road victories for the Texans, Broncos, Raiders and 49ers. In the marquee battles with major playoff implications, the computer picks the Cowboys to edge the Eagles 27-25 and the Lions to eke past San Diego 29-28. Both would be OVER bets if those scores hold up.

The computer has the Jets winning the Battle of New York over the Giants, 27-22. Both teams are in desperate need of victories. Check out the latest Week 16 NFL picks (and last week’s results below) and matchup stats, trends and previews on every game at Odds Shark.

Road

Score

Home

Score

Spread

ATS

Total

OU

Houston

28.8

Indianapolis

8

6.5

HOU

40

U

Arizona

18.5

Cincinnati

22.4

-5.5

ARI

40

O

Cleveland

12.9

Baltimore

25.6

-13.5

CLE

39

U

Tampa Bay

13.2

Carolina

22.3

-7

CAR

49

U

Minnesota

14.4

Washington

18.9

-5.5

MIN

43.5

U

Miami

24.2

NE Patriots

33

-10.5

MIA

48.5

O

St. Louis

5.3

Pittsburgh

22.9

-16.5

PIT

39

U

Denver

19.9

Buffalo

19.2

3

BUF

42.5

U

Oakland

17

Kansas City

12.5

-1

OAK

43

U

NY Giants

21.7

NY Jets

26.6

-3

NYJ

47

O

Jacksonville

12.7

Tennessee

18.9

-7.5

JAC

39

U

San Diego

28.2

Detroit

29.5

-3

SD

50.5

O

Philadelphia

25.4

Dallas

26.9

-3

PHI

50.5

O

SF 49ers

29.2

Seattle

19.9

3

SF

38

O

Chicago

26.3

Green Bay

37.8

-14

CHI

44

O

Atlanta

29

New Orleans

35.5

-7.5

ATL

53

O

Week 15 results were average at best on the NFL point spread at 9-7 but much better picking totals (picking 11 of 16 games correctly).

Road

Score

Home

Score

Spread

ATS

Total

OU

Actual

Jaxville

14.9

Atlanta

22

-10.5

JAC

42.5

U

41-14 ATL

Dallas

25.8

Tampa Bay

12.5

6.5

DAL

46.5

U

31-15 DAL

Cincinnati

21

St. Louis

6.6

6.5

CIN

38.5

U

20-13 CIN

Washington

18.2

NY Giants

21

-7.5

WAS

45.5

U

23-10 WAS

Carolina

20

Houston

32.6

-6.5

HOU

46.5

O

28-13 CAR

Seattle

19.4

Chicago

23.9

-4

CHI

35.5

O

38-14 SEA

Green Bay

38

Kansas City

13.3

14

GB

46.5

O

19-14 KC

New Orleans

35.7

Minnesota

18.8

7

NO

51

O

42-20 NO

Tennessee

22

Indianapolis

5.6

7

TEN

40.5

U

27-13 IND

Miami

22.5

Buffalo

17.7

-1

MIA

41

U

30-23 MIA

Detroit

30.1

Oakland

20.4

0

DET

48

O

28-27 DET

NY Jets

27.2

Philadelphia

23.2

-2

NYJ

45

O

45-19 PHI

Cleveland

12.9

Arizona

16

-6.5

CLE

37.5

U

20-17 ARZ

NE Patriots

33.2

Denver

21.3

4.5

NE

46.5

O

41-23 NE

Baltimore

31.1

San Diego

23.9

1

BAL

43

O

34-14 SD

Pittsburgh

25.1

SF 49ers

28.2

-1

SF

39

O

20-3 SF

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