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Come Fan with UsSunday, July 5, 2026

Tennessee Titans vs Buffalo Bills: betting odds, preview, trends, picks

The Bills have been dominated by the Titans for years. But Tennessee has been dreadful all season and bleeding money as a road team. The spread is only three points.

Rick Stewart

The Tennessee Titans are 7-1 SU and 6-2 ATS in their last eight games against the Buffalo Bills, and hope that winning trend will continue when they visit the Bills at Ralph Wilson Stadium this Sunday.

Tennessee was a 3-point road underdog, according to the football betting odds.

Tennessee got off to a historically bad start on defense this season in becoming just the second team in NFL history to give up 30 or more points through its first five games. It’s concerning as well for Titans bettors who have seen them fail to cover five straight road games, said Jeff Grant of SportsbookReview.com.

But as a 5.5-point home underdog last Thursday night, the Titans surprised the football world by holding Pittsburgh to 23 and pulling off the outright upset 26-23. With the win, Tennessee improved to 2-4 SU and ATS.

Buffalo has been hit or miss on defense all season long. The Bills have given up 45+ points three times and are 0-3 SU and ATS in those three blowout losses, but have held opponents to 17 points or less in their other three games and are 3-0 SU and ATS in those ones including last week’s upset win on the road over Arizona.

C.J. Spiller has filled in nicely for the injured Fred Jackson, but with Jackson set to return this week the running game should be even stronger for Buffalo with both backs ready to go.

Tennessee has been awful on the road this season with an 0-3 SU and ATS record. The Titans have been outscored 106-31 in those three losses to Houston, San Diego and Minnesota. Tennessee is 4-12 SU and 4-11-1 ATS in its last 16 games away from home.

Neither of these teams inspires much confidence, but Buffalo has shown more positive signs, especially on defense. The Bills are averaging 31.5 points per game at home this season, and considering how bad Tennessee’s defense is, that trend should continue this week.

It’s possible that the Titans could end up shooting out with the Bills, but at only -3.0 Buffalo should be able to cover this spread at home.

PICK: Buffalo -3 (courtesy of PickShark.com - follow us on Twitter for lines and injury updates)

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