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Come Fan with UsSunday, June 21, 2026

NFL odds and lines, Week 12: Bills vs. Colts

The Indianapolis Colts are 3.5-point favorites over the Bills on Sunday.

The Indianapolis Colts (6-4) welcome the Buffalo Bills (4-6) on Sunday as rookie Andrew Luck hopes to rebound from the first truly disappointing game of his young career.

The Colts were blown out in New England in a much-hyped showdown with Tom Brady and Patriots. Luck tossed three interceptions, including a pick-six in the fourth quarter, as Indianapolis allowed 35 points in the second half of the 59-24 loss. The Colts had won four games in a row as Luck’s legend grew, but he’ll have another tough test against a good pass defense in Buffalo.

According to OddsShark.com, the Colts are currently just 3.5-point favorites over the Bills, who used a 19-14 win over the Miami Dolphins to snap a three-game losing streak. The Bills are a tough team to nail down, losing several games by less than one score and being completely blown out on three occasions.

The over/under for the game is set at 51, a high number due to the explosive nature that both offenses possess.

Kickoff is set for 1 p.m. ET with coverage on CBS.

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