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Come Fan with UsThursday, June 25, 2026

Week 13 NFL odds: Colts vs. Lions

Detroit is an unlikely favorite against Indianapolis on Sunday afternoon.

Matthew Stockman

The Detroit Lions host the Indianapolis Colts this weekend in a game between teams traveling in opposite directions. Kickoff is set for 1:00 p.m. ET Sunday, with television coverage on CBS. Detroit enters the game as a 4.5-point favorite.

The Colts have won four of their last five contests, both straight up and against the spread. Rookie quarterback Andrew Luck has thrown for 3205 yards and 13 touchdowns in eleven games, including 240 yards and a score against Buffalo last week. The total yardage is enough to make Luck the NFL's seventh-leading passer. Despite that fact, the Colts are averaging just 20.9 points per game, due in large part to struggles in the running game.

Oh the other hand, Detroit has compiled some phenomenal offensive statistics through eleven games. Quarterback Matt Stafford leads the league in passing with 3429 yards. Wide receiver Calvin Johnson is fifth in the NFL in receptions, but leads the league in receiving yards. Despite the prolific Detroit passing attack, the Lions are 4-7 on the season and losers of three consecutive games.

For more on the Detroit-Indianapolis matchup and the other NFL odds, go to Oddsshark.com.

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