Skip to main content
Come Fan with UsSaturday, June 20, 2026

Week 15 NFL picks: 49ers vs. Patriots

In a meeting of two division leaders, experts like the Patriots over the 49ers on Sunday night.

The New England Patriots and San Francisco 49ers are both headed to the playoffs, and when the two teams meet Sunday night in Foxboro, the Patriots are favored to emerge victorious.

Depending on where you look, New England is anywhere from a 5- to 6-point favorite. Experts agree that, by the end of the night, the Patriots will have improved to 11-3 on the year.

Analysts at CBSSports.com almost unanimously picked New England, with Will Brinson the only one out of eight going with the 49ers.

The Patriots come into the game winners of seven straight, having not lost at home since Sept. 16. Of course, Tom Brady and his 29 touchdown passes lead the offensive attack, while Stevan Ridley has rushed for 10 touchdowns and over 1000 yards in 2012.

Les Carpenter and Mike Silver from Yahoo! Sports agree that the Patriots have the upper hand, but Jason Cole is going with San Francisco. The 49ers have the second-best passing defense in the NFL, so if anyone is going to stop Brady and New England, maybe it’s San Francisco.

See More:

More in NFL

NFL
WNFC championship game airing Sunday, June 21st from Ford Center in FriscoWNFC championship game airing Sunday, June 21st from Ford Center in Frisco
NFL

The Women’s National Football Conference Championship will air on ESPN2 this weekend.

By RJ Ochoa
From SBNationExternal Link
Which fictional quarterback would you have lead your team?Which fictional quarterback would you have lead your team?
From SBNationExternal Link
By James Dator
NFL
Best bets for 2026 NFL Offensive Rookie of the YearBest bets for 2026 NFL Offensive Rookie of the Year
NFL

There are some good longer-shot options on offensive side of ball for the NFL’s Rookie of the Year.

By Bill Williamson
NFL
Brendan Sorsby is a rare chance to get a top QB cheap, and these teams should go inBrendan Sorsby is a rare chance to get a top QB cheap, and these teams should go in
NFL

This is a no-brainer for some NFL teams.

By James Dator
NFL
Fernando Mendoza has great respect for the Raiders that came before himFernando Mendoza has great respect for the Raiders that came before him
NFL

Fernando Mendoza has great respect for the Raiders that came before him

By RJ Ochoa
NFL
Brendan Sorsby intends to enter NFL Supplemental Draft, per reportsBrendan Sorsby intends to enter NFL Supplemental Draft, per reports
NFL

Texas Tech quarterback Brendan Sorsby is entering the NFL Supplemental Draft, per reports

By Mark Schofield