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Come Fan with UsFriday, August 7, 2026

NFL picks Week 17: Cardinals vs. 49ers

We’ve done a little digging to see what the pros think about this NFC West contest.

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Ezra Shaw

In a battle between NFC West division foes, the Week 17 game between the San Francisco 49ers and Arizona Cardinals at Candlestick Park is a contest that has very different implications for each team.

At its surface, it’s a lopsided affair between a Niners team with a chance at a first-round bye on the line against a team with nothing to lose in Arizona. If recent history is any indicator, then the 49ers’ Week 8 24-3 rout over the Cardinals could be a microcosm of what can happen when the 49ers have their turn to play host.

But what do the experts think?

The experts at Yahoo! Sports have the 49ers taking care of business at home. Every member of their panel selected San Francisco. The same goes for USA Today. Accuscore supports each of those sites and says that the Niners have an 87 percent chance of emerging victorious.

Given the stakes, talent disparity and strong support from experts, it appears that the 49ers will have no issues ending their season on a high note.

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