Skip to main content
Come Fan with UsSaturday, June 20, 2026

Isaac Guerendo injury update: 49ers RB goes to locker room in fourth quarter vs. Bears

The 49ers backfield is further and further depleted. Running back Isaac Guerendo is the latest to suffer an injury. We break down the implications and provide updates.

Isaac Guerendo #31 of the San Francisco 49ers celebrates after a fourth quarter touchdown against the Chicago Bears at Levi’s Stadium on December 08, 2024 in Santa Clara, California.
Isaac Guerendo #31 of the San Francisco 49ers celebrates after a fourth quarter touchdown against the Chicago Bears at Levi’s Stadium on December 08, 2024 in Santa Clara, California.
Photo by Thearon W. Henderson/Getty Images

The San Francisco 49ers have been ravaged by injuries this season, and the running back position might be dealing with more than any other unit. Third string running back Isaac Guerendo had to leave Sunday’s game against the Chicago Bears with a foot injury. He was spotted walking to the locker room with training staff and was announced as questionable to return.

Guerendo had 78 rushing yards and two touchdowns along with 50 receiving yards in the 49ers Week 14 contest. He replaced Christian McCaffrey and Jordan Mason, who were both previously placed on injured reserve.

Patrick Taylor has replaced Guerendo in the 49ers backfield with Deebo Samuel also getting rushing work. Ke’Shawn Vaughn made an appearance late in the game after joining the team earlier this week to add roster depth.

More in NFL

NFL
WNFC championship game airing Sunday, June 21st from Ford Center in FriscoWNFC championship game airing Sunday, June 21st from Ford Center in Frisco
NFL

The Women’s National Football Conference Championship will air on ESPN2 this weekend.

By RJ Ochoa
From SBNationExternal Link
Which fictional quarterback would you have lead your team?Which fictional quarterback would you have lead your team?
From SBNationExternal Link
By James Dator
NFL
Best bets for 2026 NFL Offensive Rookie of the YearBest bets for 2026 NFL Offensive Rookie of the Year
NFL

There are some good longer-shot options on offensive side of ball for the NFL’s Rookie of the Year.

By Bill Williamson
NFL
Brendan Sorsby is a rare chance to get a top QB cheap, and these teams should go inBrendan Sorsby is a rare chance to get a top QB cheap, and these teams should go in
NFL

This is a no-brainer for some NFL teams.

By James Dator
NFL
Fernando Mendoza has great respect for the Raiders that came before himFernando Mendoza has great respect for the Raiders that came before him
NFL

Fernando Mendoza has great respect for the Raiders that came before him

By RJ Ochoa
NFL
Brendan Sorsby intends to enter NFL Supplemental Draft, per reportsBrendan Sorsby intends to enter NFL Supplemental Draft, per reports
NFL

Texas Tech quarterback Brendan Sorsby is entering the NFL Supplemental Draft, per reports

By Mark Schofield

Comments
Loading comments
Getting the conversation ready...