Skip to main content
Come Fan with UsWednesday, July 1, 2026

Monday Night Football betting: odds favor home teams in Week 1

The Giants and Chargers are underdogs in the MNF doubleheader. After Sunday’s parade of underdog winners, will bettors bank them at Detroit and Arizona, respectively?

Raj Mehta-USA TODAY Sports

Do football bettors automatically side with the underdogs on Monday night after the favorites were demolished 10-3 against the spread on Sunday?

If so, sportsbooks should expect a flood of money on the Giants as five-point underdogs at Detroit and on the Chargers, who are +2.5 at Arizona.

Sportsbooks had one of their best regular-season days ever Sunday when underdogs clobbered the chalk. Only a second-half rally by the Eagles against Jacksonville saved that game from also going to the dogs, according to Odds Shark.

So with a pair of Monday Night Football clashes going to open the season, it’s a chance for bettors to hide their wallets until Week 2 or to try to reclaim some Sunday losses.

Giants at Lions

New York has been a profitable play on Monday nights, covering the spread in eight of their past 12 trips to the national limelight. However, the past five times they opened the season on the road, they failed to cover.

Detroit, meanwhile, has seen a solid 63 percent of the betting consensus backing them. They are 8-3 ATS in their past 11 openers but are just 1-5 ATS in their past six games as home favorites.

Odds Shark Prediction: 22-16 Detroit

Chargers at Cardinals

Arizona has covered just one Monday Night Football spread in eight tries since 1995. Meanwhile the Chargers are riding a 4-1 ATS in the same situation.

The Cardinals have been a great bet in Week 1 in recent years, rolling to a 5-1 ATS profit in six seasons. But put them against the Chargers, and the Cards have limped to a bankroll-bleeding 2-7 SU mark since 1987.

This situation has been a boon to San Diego bettors as they are enjoying an 8-1-1 ATS streak in their past 10 games as road underdogs.

Odds Shark Prediction: 26-24 Arizona

Sports Odds, Lines And Betting News
6 Super Bowl 60 prop bet picks for Seahawks vs. Patriots6 Super Bowl 60 prop bet picks for Seahawks vs. Patriots
Sports Odds, Lines And Betting News

There are some fun prop bets on the board for Super Bowl 60

By Bill Williamson
NFL
What Super Bowl odds tell us about the final four teamsWhat Super Bowl odds tell us about the final four teams
NFL

The Seahawks head into the conference championships as the Super Bowl 60 favorite. We break down the odds of the final four teams.

By David Fucillo
NFL
Opening odds for 49ers-Seahawks in 2026 NFC Divisional roundOpening odds for 49ers-Seahawks in 2026 NFC Divisional round
NFL

The NFC Divisional round is set. We break down the opening odds for 49ers-Seahawks.

By Nick Simon
Sports Odds, Lines And Betting News
Opening odds for Rams-Bears in 2026 NFC Divisional roundOpening odds for Rams-Bears in 2026 NFC Divisional round
Sports Odds, Lines And Betting News

The NFC Divisional round is set. We break down the opening odds for Rams-Bears.

By Nick Simon
Women's College Basketball
3 women’s college basketball teams with enticing 2026 national championship odds3 women’s college basketball teams with enticing 2026 national championship odds
Women's College Basketball

UConn and South Carolina are the favorites, but other women’s college basketball teams have enticing title odds.

By Mitchell Northam
Men's College Basketball
March Madness odds: Chances for every team in the 2025 NCAA tournament to win the titleMarch Madness odds: Chances for every team in the 2025 NCAA tournament to win the title
Men's College Basketball

Cooper Flagg leads Duke to be the tournament favorite.

By James Dator and David Fucillo