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Come Fan with UsSaturday, June 20, 2026

College football odds 2017, Week 6: The opening lines for the biggest games

NC State hosts Louisville as home underdogs to kick off the Week 6 betting slate.

Jamie Rhodes-USA TODAY Sports

The No. 24 NC State Wolfpack are 3-13 straight up and 6-10 against the spread in their last 16 games played in the month of October. The Wolfpack hope to buck that trend with an upset win this Thursday night over the No. 17 Louisville Cardinals.

NC State is a 2.5-point home underdog at sportsbooks monitored by OddsShark.com. Louisville has won each of the last three games in this head-to-head series and will try to stay in the ACC title picture with a win in this game. Lamar Jackson passed for 355 yards and three touchdowns and rushed for 76 yards and a touchdown in last year’s 54-13 win over NC State.

College Football Week 6 Odds

Alabama (-25.5) at Texas A&M

Wake Forest at Clemson (-21.5)

Georgia (-16.5) at Vanderbilt

Penn State (-14) at Northwestern

Michigan State at Michigan (-14)

West Virginia at TCU (-12.5)

Miami (-3) at Florida State

Louisville (-2.5) at North Carolina State

See the complete list at OddsShark.

Staying in the ACC, the No. 2 Clemson Tigers will try to cash in as a 21.5-point favorite at home against the Wake Forest Demon Deacons. The Tigers are 8-0 SU in their last eight games against the Demon Deacons but 0-3 ATS in their last three against them. Wake Forest is 5-1 SU and 4-1-1 ATS in its last six games overall.

No. 1 Alabama has been on an absolute tear over the last two weeks, crushing Vanderbilt 59-0 and Ole Miss 66-3. The Crimson Tide will look to keep rolling on the road this Saturday against the Texas A&M Aggies. Alabama is 8-0 ATS in its last eight road games against teams with winning records.

Two other Top 5 teams are on the road this week as No. 4 Penn State (-14) visits Northwestern and No. 5 Georgia (-16.5) visits Vanderbilt. The Bulldogs have climbed into the Top 5 on the heels of a 5-0 SU and 4-1 ATS start to the season that includes a 41-0 win over Tennessee last week.

Saturday’s only game between two ranked teams pits No. 23 West Virginia against No. 8 TCU. TCU picked up a statement win two Saturdays ago as a 9.5-point road underdog at Oklahoma State. The Horned Frogs are 12.5-point favorites this Saturday at home against West Virginia. TCU is 7-2 SU in its last nine games played in Week 6.

Other top games this week include Michigan State at No. 7 Michigan (-14) and No. 13 Miami (-3) at Florida State.

For more info, picks and a breakdown of this week’s top sports betting news check out the new OddsShark podcast with Jon Campbell and Andrew Avery. Subscribe on iTunes, or check it out at OddsShark.libsyn.com.

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