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Come Fan with UsSaturday, June 20, 2026

College football odds, Week 1: Massive FSU vs. Alabama clash highlights week

The meeting between the Crimson Tide and Seminoles leads the Week 1 betting card.

NCAA Football: Alabama Spring Game-A-Day
NCAA Football: Alabama Spring Game-A-Day
Marvin Gentry-USA TODAY Sports

The Alabama Crimson Tide are 23-0 straight up and 15-8 against the spread over their last 23 regular season games. That streak will be put to the test this Saturday when the Crimson Tide face the Florida State Seminoles at the new Mercedes-Benz Stadium in Atlanta, Ga.

Alabama is a 7-point favorite in Atlanta at sportsbooks monitored by OddsShark.com. With the Crimson Tide entering the season ranked No. 1 in the AP Top 25 Poll and Florida State ranked No. 3, this matchup could have massive playoff implications.

The Crimson Tide started off last season with a statement win in a 52-6 victory as a 13-point favorite against the USC Trojans.

College Football Week 1 Betting Lines (see the complete list at OddsShark)

  • Western Michigan at USC (-27)
  • Florida State vs. Alabama (-7)
  • West Virginia vs. Virginia Tech (-4.5)
  • Michigan (-4) vs. Florida

Those Trojans will also be in action on Saturday as the Heisman Trophy favorite Sam Darnold gets the chance to build up some stats early against the Western Michigan Broncos. USC ended 2016 on a 9-0 SU and 7-2 ATS run and will try to build on that success and win the Pac-12 for the first time since 2008.

Western Michigan is 15-1 SU and 11-4-1 ATS over its last 16 games, but the Broncos have some rebuilding to do with former head coach P.J. Fleck and quarterback Zach Terrell no longer with the team. They are a 27-point road underdog at USC.

While not as big of a game as Alabama vs. Florida State, No. 11 Michigan (-4) vs. No. 17 Florida at AT&T Stadium in Arlington, Texas figures to be another highlight on this week’s betting card. Both of these teams had a disappointing finish to 2016, with Michigan going 1-3 SU and ATS over its last four games and Florida going 1-2 SU and ATS over its last two.

Jim Harbaugh has done a fine job of building Michigan back up into a contender, but the Wolverines still need to prove they can win on the road. The Wolverines are 3-7 SU and 2-8 ATS in their last 10 games as a road favorite of a touchdown or less per the OddsShark College Football Database.

In the final game between two ranked teams this weekend, the No. 21 Virginia Tech Hokies (-4.5) and the No. 22 West Virginia Mountaineers meet at FedExField in Landover, Md. on Sunday. Both teams got to 10 wins in 2016.

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