Skip to main content
Come Fan with UsSaturday, June 20, 2026

USC, Ohio State, Clemson among Week 2’s big betting favorites

Here are some of Week 2’s biggest early lines and trends.

NCAA Football: Western Michigan at Southern California
NCAA Football: Western Michigan at Southern California
Kirby Lee-USA TODAY Sports

The USC Trojans are 0-3 straight up and against the spread in their last three games against the Stanford Cardinal. The Trojans will try to snap that losing streak with a win at home over Stanford on Saturday.

USC is a 7-point betting favorite at the Coliseum at sportsbooks monitored by OddsShark.com. The line opened at some books with the Trojans as a 4-point favorite, but the betting public pounded the home team all the way up to 7 points over the weekend.

Bettors seem undeterred by the fact that USC looked shaky in its 49-31 home win over Western Michigan and Stanford looked extremely sharp in a 62-7 blowout over Rice in Australia.

Stanford at USC is one of three games this week being played between two teams in the AP Top 25. The others are Auburn at Clemson (-6.5) and Oklahoma at Ohio State (-7.5). Georgia at Notre Dame may be added to this list as well if Notre Dame cracks the Top 25 this week on the heels of a 49-16 win over Temple.

College Football Week 2 Odds (see the complete list at OddsShark)

  • Fresno State at Alabama (-42.5)
  • Cincinnati at Michigan (-33)
  • Miami (-13.5) at Arkansas State
  • Louisville (-8) at North Carolina
  • Oklahoma at Ohio State (-7.5)
  • Stanford at USC (-7)
  • Auburn at Clemson (-6.5)
  • Georgia at Notre Dame (No Line)

Oklahoma got embarrassed by Ohio State on its home field last season, falling to the Buckeyes, 45-24. That loss sparked a 10-0 SU and 7-3 ATS run to end the season for the Sooners, who will try to return the favor this year by handing the Buckeyes a loss on their stomping grounds.

The Buckeyes are 5-2 SU and 6-1 ATS in their last seven games against Big 12 opponents per the OddsShark College Football Database.

Two teams that will have to avoid trap games on the road this week are the Miami Hurricanes (-13.5) at Arkansas State and the Louisville Cardinals (-8) at North Carolina. Miami plays one of the biggest games on its schedule next week at Florida State, and Louisville will be hosting the defending champion Clemson Tigers next week.

Neither team can afford to look ahead while facing potentially dangerous home teams on Saturday.

For Alabama and Michigan, the proceedings figure to be a lot easier on Saturday. The Crimson Tide and Wolverines both picked up impressive wins against ranked teams last Saturday, and will get much easier tasks this weekend as Michigan is a 33-point home favorite against Cincinnati and Alabama hosts Fresno State as a 42-point home favorite.

Sports Odds, Lines And Betting News
6 Super Bowl 60 prop bet picks for Seahawks vs. Patriots6 Super Bowl 60 prop bet picks for Seahawks vs. Patriots
Sports Odds, Lines And Betting News

There are some fun prop bets on the board for Super Bowl 60

By Bill Williamson
NFL
What Super Bowl odds tell us about the final four teamsWhat Super Bowl odds tell us about the final four teams
NFL

The Seahawks head into the conference championships as the Super Bowl 60 favorite. We break down the odds of the final four teams.

By David Fucillo
NFL
Opening odds for 49ers-Seahawks in 2026 NFC Divisional roundOpening odds for 49ers-Seahawks in 2026 NFC Divisional round
NFL

The NFC Divisional round is set. We break down the opening odds for 49ers-Seahawks.

By Nick Simon
Sports Odds, Lines And Betting News
Opening odds for Rams-Bears in 2026 NFC Divisional roundOpening odds for Rams-Bears in 2026 NFC Divisional round
Sports Odds, Lines And Betting News

The NFC Divisional round is set. We break down the opening odds for Rams-Bears.

By Nick Simon
Women's College Basketball
3 women’s college basketball teams with enticing 2026 national championship odds3 women’s college basketball teams with enticing 2026 national championship odds
Women's College Basketball

UConn and South Carolina are the favorites, but other women’s college basketball teams have enticing title odds.

By Mitchell Northam
Men's College Basketball
March Madness odds: Chances for every team in the 2025 NCAA tournament to win the titleMarch Madness odds: Chances for every team in the 2025 NCAA tournament to win the title
Men's College Basketball

Cooper Flagg leads Duke to be the tournament favorite.

By James Dator and David Fucillo