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Come Fan with UsTuesday, August 4, 2026

Opening lines and betting trends for all *7* of college football’s ranked-vs.-ranked Week 10 games

Here’s what the sportsbooks and the recent data have to say about maybe the biggest weekend yet.

Texas v Oklahoma State
Texas v Oklahoma State
Photo by Brett Deering/Getty Images

No. 8 Oklahoma visits No. 11 Oklahoma State (-3) in a battle to try to stay alive in the Big 12 title picture. Oklahoma State is just 2-12 SU in its last 14 games against its cross-state rival. Oklahoma is 9-0 SU and 6-3 ATS in its last nine games played in the month of November.

College Football Week 10 Odds

LSU at Alabama (-21.5)

Penn State (-7.5) at Michigan State

Arizona at USC (-7.5)

Clemson (-7) at NC State

Oklahoma at Oklahoma State (-3)

Virginia Tech (-2.5) at Miami

Stanford at Washington State (-2.5)

Ohio State (-16.5) at Iowa

See the complete list at OddsShark

The No. 19 LSU Tigers are 0-6 straight up in their last six games against the No. 1 Alabama Crimson Tide and 0-3-1 against the spread in the last four games in this series. The Tigers will try to turn things around against Alabama this Saturday on the road.

LSU is a 21.5-point road underdog in Alabama at sportsbooks monitored by OddsShark.com. Both of these teams enter this game coming off a bye week. Alabama is 6-1 SU and 4-2-1 ATS in its last seven games after a bye week while LSU is 2-5 SU in its last seven games out of a bye.

At 7-0 SU and 3-4 ATS, the No. 9 Miami Hurricanes are still trying to prove that they belong in the College Football Playoff conversation. They will have a chance to make a statement this Saturday as 2.5-point home underdogs hosting the No. 13 Virginia Tech Hokies. The road team is 3-7 SU in the last 10 meetings between these two teams per the OddsShark College Football Database.

Rounding out the games between two ranked teams this Saturday are matchups of No. 6 Clemson (-7) at No. 20 NC State, No. 7 Penn State (-7.5) at No. 24 Michigan State, No. 23 Arizona at No. 17 USC (-7.5), and No. 18 Stanford at No. 25 Washington State (-2.5).

With last Saturday’s 39-38 loss to the Ohio State Buckeyes, Penn State no longer controls its own destiny in the Big Ten. The Nittany Lions will need to win out to keep their playoff hopes alive, and will have to start with a win Saturday in East Lansing. Michigan State is 3-1 SU and ATS in its last four games against Penn State. Ohio State is now up to No. 3 in the AP Top 25 and is a 16.5-point road favorite at Iowa Saturday.

For more info, picks and a breakdown of this week’s top sports betting news check out the new OddsShark podcast with Jon Campbell and Andrew Avery. Subscribe on iTunes, or check it out at OddsShark.libsyn.com.

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