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Come Fan with UsTuesday, August 4, 2026

Top college football teams take the road as big favorites in Week 4’s opening lines

Here are the early spreads for the biggest games of next weekend.

Georgia State v Penn State
Georgia State v Penn State
Photo by Justin K. Aller/Getty Images

There are two games on the board between two ranked teams this Saturday. No. 11 Georgia hosts No. 17 Mississippi State as a 6.5-point betting favorite and No. 6 Oklahoma State hosts No. 16 TCU as a 12-point favorite. Oklahoma State is 33-3 SU in its last 36 games played in the month of September.

Four of the top five teams in the current AP Top 25 rankings are on the road this Saturday: No. 1 Alabama (-18.5) at Vanderbilt, the No. 3 Sooners (-26.5) at Baylor, No. 4 Penn State (-12.5) at Iowa, and No. 5 USC at California.

College Football Week 4 Odds

Boston College at Clemson (-34)

Alabama (-18.5) at Vanderbilt

Oklahoma (-26.5) at Baylor

Penn State (-12.5) at Iowa

USC (16) at California

TCU at Oklahoma State (-12)

Washington (-10) at Colorado

Mississippi State at Georgia (-6.5)

(See the complete list at OddsShark)

The Oklahoma Sooners are 12-0 straight up and 9-3 against the spread in their last 12 games on the road. The Sooners will try to extend their road winning streak this Saturday night against the Baylor Bears. Oklahoma is a 26.5-point favorite at Baylor at sportsbooks monitored by OddsShark.com.

Baylor’s season is off to a disastrous start, losing back-to-back games as double-digit favorites at home to Liberty and UTSA and then losing 34-20 at Duke last week. The Bears are 0-9 SU and 1-8 ATS over their last nine regular season games.

Alabama is 11-0 SU in its last 11 road games and 7-1 ATS over its last eight per the OddsShark College Football Database. The Crimson Tide have also won each of their last 11 games against Vanderbilt.

Penn State hasn’t failed to cover the spread in any of its last 12 games going 11-0-1 ATS over that stretch. The Nittany Lions are just 1-4 SU in their last five trips to Iowa, however. Iowa has won 13 of its last 16 games at home outright.

USC survived a scare against Texas last Saturday as 16.5-point favorites and now will face its first road test of the season at Cal. The Trojans haven’t lost to Cal since 2003, owning a 13-0 SU and 10-3 ATS record in their last 13 games against their Pac-12 rival.

Other games featuring top teams this week include Boston College at No. 2 Clemson (-34) and No. 7 Washington (-10) at Colorado. Washington is a perfect 7-0 SU and ATS in its last seven games against Colorado.

For more info, picks and a breakdown of this week’s top sports betting news, check out the new OddsShark podcast with Jon Campbell and Andrew Avery. Subscribe on iTunes, or check it out at OddsShark.libsyn.com.

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