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Come Fan with UsTuesday, August 4, 2026

College football odds, Week 6: Oklahoma, LSU, Notre Dame among betting favorites

Oklahoma faces Texas in the Red River Showdown and LSU and Notre Dame are on the road as Week 6 of the college football odds slate takes shape at the sportsbooks.

NCAA Football: Baylor at Oklahoma
NCAA Football: Baylor at Oklahoma
Kevin Jairaj-USA TODAY Sports

The No. 7 Oklahoma Sooners are 12-0 straight up and 6-6 against the spread in their last 12 games as a betting favorite. The Sooners will try to extend their winning streak as a favorite this Saturday when they take on the No. 19 Texas Longhorns in Dallas.

Oklahoma is a 7.5-point favorite on the college football odds at the Cotton Bowl at sportsbooks monitored by OddsShark.com. Since losing its season-opening game to Maryland, Texas has won each of its last four games, including impressive wins over TCU and USC. The Longhorns have covered the spread in each of their last five games played in the month of November.

Elsewhere, the Notre Dame Fighting Irish have moved up to No. 6 in the AP Top 25 coming off an impressive 38-17 win over the Stanford Cardinal last Saturday. This Saturday, the Fighting Irish are a 5-point road favorite visiting the No. 24 Virginia Tech Hokies. Virginia Tech is 12-0 SU and 10-2 ATS in its last 12 games against independent schools.

College Football Week 6 Betting Lines

Alabama (-34) at Arkansas

Vanderbilt at Georgia (-26.5)

Indiana at Ohio State (-25)

Texas vs. Oklahoma (-7.5)

Kentucky at Texas A&M (-6)

Notre Dame (-5) at Virginia Tech

LSU (-3.5) at Florida

Clemson (-17.5) at Wake Forest

See the complete list at OddsShark

The No. 5 LSU Tigers are on the road Saturday to take on the No. 22 Florida Gators. LSU passed its first big road test two weeks ago at Auburn and will now face another one as 3.5-point road favorites. The Tigers are 4-1 SU in their last five games against Florida. Things don’t get any easier for LSU with a matchup against No. 2 Georgia coming up at home next Saturday.

Georgia doesn’t have nearly as tough of a game this week heading into that big matchup as it is a 26.5-point favorite at home against Vanderbilt. The Bulldogs are 20-3 SU in their last 23 games against the Commodores.

The rest of the top-five teams in action also have soft opponents this week as No. 1 Alabama (-34) visits Arkansas, No. 3 Ohio State (-25) hosts Indiana, and No. 4 Clemson (-17.5) visits Wake Forest.

And in one of the biggest surprises of the 2018 season, the Kentucky Wildcats are off to a 5-0 SU and 3-2 ATS start, earning them a No. 13 ranking. Kentucky is a 6-point underdog this Saturday on the road against the Texas A&M Aggies.

For more odds information, betting picks, and a breakdown of this week’s top sports betting news check out the OddsShark podcast with Jon Campbell and Andrew Avery. Subscribe on iTunes or Spotify or listen to it at OddsShark.libsyn.com.

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