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Come Fan with UsSaturday, June 20, 2026

College football odds, Week 3: Betting lines and trends for the top games of the week

The Oklahoma Sooners are one of three Top 5 teams on the road this Saturday facing Iowa State, and they’re also one of the big betting favorites at the sportsbooks.

NCAA Football: UCLA at Oklahoma
NCAA Football: UCLA at Oklahoma
Mark D. Smith-USA TODAY Sports

The No. 5 Oklahoma Sooners were 14-0 straight up and 10-4 against the spread in their previous 14 games when they shockingly lost to the Iowa State Cyclones at home last season as 31-point favorites. The Sooners are 10-1 SU and 6-5 ATS since that loss and will look to avenge it this Saturday at Iowa State.

Oklahoma is an 18-point road favorite on the college football odds for Week 3 at sportsbooks monitored by OddsShark.com. The Sooners are 14-1 SU and 9-6 ATS in 15 meetings with the Cyclones since 1995 and would love to get back on the track of regularly crushing this team with a big win this year. Over their last 16 road games the Sooners are 16-0 SU and 10-6 ATS according to the OddsShark College Football Database.

The No. 1 Alabama Crimson Tide are also on the road this week visiting the Ole Miss Rebels as 19.5-point favorites. On paper this shouldn’t be much of a contest, but the Rebels are 2-2 SU and 3-1 ATS in their last four games against Alabama, giving these head-to-head matchups a bit of intrigue. The Crimson Tide are 12-0 SU in their last 12 games played in September.

College Football Week 3 Betting Lines

Georgia Southern at Clemson (-34.5)

Middle Tennessee at Georgia (-31)

BYU at Wisconsin (-23)

Oklahoma (-18) at Iowa State

Alabama (-19.5) at Ole Miss

Ohio State (-13) vs TCU

LSU at Auburn (-10)

Boise State at Oklahoma State (-3.5)

See the complete list at OddsShark

The Top 5 team receiving the toughest test on the road this week is the No. 4 Ohio State Buckeyes going off at -13 against the No. 15 TCU Horned Frogs in a game that will be played at AT&T Stadium in Arlington. Both of these teams enter this game in strong form with TCU coming in at 2-0 with wins of 55-7 and 42-12 and Ohio State coming in at 2-0 with wins of 77-31 and 52-3. Ohio State is 6-2 ATS in its last eight games against Big 12 opponents.

Rounding out the top six teams in the AP Top 25 rankings are three big favorites at home in Georgia Southern at No. 2 Clemson (-34.5), Middle Tennessee at No. 3 Georgia (-31) and BYU at No. 4 Wisconsin (-23).

Joining Ohio State vs. TCU in the games featuring two ranked teams on the card, No. 12 LSU visits No. 7 Auburn (-10) on Saturday and No. 17 Boise State is on the road against No. 24 Oklahoma State (-3.5). Oklahoma State is a perfect 8-0 ATS in its last eight games played in Week 3.

For more odds information, betting picks and a breakdown of this week’s top sports betting news check out the OddsShark podcast with Jon Campbell and Andrew Avery. Subscribe on iTunes or listen to it at OddsShark.libsyn.com.

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