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Come Fan with UsTuesday, June 23, 2026

Frank Gore injury: 49ers RB listed as probable, should be a must-start for fantasy owners

San Francisco 49ers running back Frank Gore is expected to play Sunday against a tough Arizona defense

Cary Edmondson-USA TODAY Sports

San Francisco 49ers running back Frank Gore is listed as probable on the official injury report. Gore is dealing with a knee injury, but was a full participant in practice on Friday. Gore has been somewhat injury-prone in recent years, so he's been a concern, but it would be surprising if he missed any time.

Gore has been productive in recent wees, picking up 81 yards and a touchdown in a Week 5 win over the Houston Texans. The week prior, he had 20 carries for 153 yards and a touchdown against the St. Louis Rams. Gore is the bell cow of the San Francisco offense, taking control after quarterback Colin Kaepernick struggled for a few games.

Fantasy Impact: While Gore might not be the top fantasy running back these days, the 49ers are clearly going to continue to run him around 20 times a game. He seems in line for another 1,000-yard season and should be a must-start if he's likely to play, which he is. The only caveat here is that the Cardinals have one of the top run defenses in the NFL. Still, fantasy owners should stick with him until he shows otherwise.

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